Volume 26, Number 9—September 2020
Research
Detection of H1 Swine Influenza A Virus Antibodies in Human Serum Samples by Age Group1
Elien Vandoorn, Isabel Leroux-Roels, Geert Leroux-Roels, Anna Parys, Amy Vincent, and Kristien Van Reeth
Table 5
Antigenic distance in units between human and swine H1 IAVs in cross-hemagglutination inhibition assays (upper right) and cross-virus neutralization assays (lower left)*
| Virus strain |
Eurasian avian |
Human seasonal |
Classical swine |
||||||||||
| swG10 |
swHK11 |
TW86† |
swG12 |
NC99† |
swAL16 |
swIL10 |
swOK13 |
BR07† |
swOH07 |
CA09 |
|||
| Europe 1C.2.1 |
Asia 1C.2.3 |
1B.1-like |
Europe 1B.1.2.1 |
1B.2-like |
N. Am. 1B.2.2.1 |
N. Am. 1B.2.2.2 |
N. Am. 1B.2.2.2 |
1B.2-like |
N. Am. 1A.3.3.3 |
World 1A.3.3.2 |
|||
| swG10 | – | 1.67 | 4.96 | 4.67 | 4.49 | 4.15 | 4.30 | 4.24 | 4.69 | 4.41 | 4.23 | ||
| swHK11 |
1.93 |
– |
5.20 |
5.03 |
4.77 |
4.53 |
4.69 |
4.50 |
4.92 |
3.75 |
3.82 |
||
| TW86 | 4.84 | 4.98 | – | 2.12 | 4.77 | 4.54 | 4.79 | 4.80 | 5.14 | 5.63 | 5.54 | ||
| swG12 |
4.87 |
5.09 |
2.31 |
– |
4.77 |
4.33 |
4.74 |
4.77 |
5.14 |
5.65 |
5.53 |
||
| NC99 | 4.65 | 4.37 | 4.72 | 4.85 | – | 2.62 | 3.04 | 4.35 | 2.74 | 5.19 | 5.08 | ||
| swAL16 | 4.62 | 4.53 | 4.79 | 4.71 | 1.75 | – | 2.65 | 3.99 | 3.67 | 4.91 | 4.75 | ||
| swIL10 | 4.95 | 4.93 | 5.27 | 5.19 | 2.50 | 2.29 | – | 4.11 | 2.75 | 5.09 | 4.92 | ||
| swOK13 |
4.34 |
4.44 |
4.79 |
4.83 |
4.47 |
4.44 |
4.63 |
– |
4.56 |
4.65 |
4.81 |
||
| BR07 |
4.77 |
4.36 |
4.97 |
5.06 |
1.91 |
2.75 |
2.75 |
4.63 |
– |
5.35 |
5.26 |
||
| swOH07 | 4.65 | 3.48 | 5.07 | 5.21 | 4.71 | 4.80 | 5.12 | 4.73 | 4.44 | – | 1.43 | ||
| CA09 |
4.59 |
3.91 |
4.89 |
5.28 |
5.09 |
5.01 |
5.33 |
4.53 |
5.17 |
2.06 |
– |
||
| *Viruses are ordered chronologically according to the year of circulation of the selected human test viruses TW86, NC99, BR07, and CA09; horizontal rules within table represent grouping of epidemiologically related human and swine influenza A viruses, with the oldest (ancestor) virus mentioned first. Complete isolate names are provided in Table 1. IAV, influenza A virus; N. Am., North America; – not applicable. †Human IAV that no longer circulates; TW86 is the presumed human precursor for human-like H1 swine IAVs in Europe; NC99 is the presumed human precursor for human-like H1 swine IAVs in North America; BR07 is a human seasonal IAV that circulated right before the influenza A(H1N1)pdm09 virus; the influenza A(H1N1)pdm09 virus, represented by CA09, is circulating in both humans and swine worldwide. | |||||||||||||
1Preliminary results from this study were presented at the Fourth International Symposium on Neglected Influenza Viruses, April 18–20, 2018, Brighton, United Kingdom; at the BELVIR conference, December 20, 2018, Brussels, Belgium; and at the 1918 Pandemic Conference, February 7–8, 2019, Ypres, Belgium.
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