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Volume 26, Number 9—September 2020
Research

Detection of H1 Swine Influenza A Virus Antibodies in Human Serum Samples by Age Group1

Elien Vandoorn, Isabel Leroux-Roels, Geert Leroux-Roels, Anna Parys, Amy Vincent, and Kristien Van ReethComments to Author 
Author affiliations: Ghent University, Merelbeke, Belgium (E. Vandoorn, A. Parys, K. Van Reeth); Ghent University and Ghent University Hospital, Ghent, Belgium (I. Leroux-Roels, G. Leroux-Roels); National Animal Disease Center, Ames, Iowa, USA (A. Vincent)

Main Article

Table 7

Geometric mean of virus neutralization titers and antibody reactivity against different human and swine H1 influenza A viruses in different age groups of the population, 2017–2018, Belgium*

Birth year range
(age, y‡) Eurasian avian
Human seasonal
Classical swine
swG10
swHK11
TW86†
swG12
NC99†
swAL16
swIL10
swOK13
BR07†
swOH07
CA09
Europe 1C.2.1
Asia 1C.2.3 1B.1-like Europe 1B.1.2.1 1B.2-like N. Am. 1B.2.2.1 N. Am. 1B.2.2.2 N. Am. 1B.2.2.2 1B.2-like N. Am. 1A.3.3.3 World 1A.3.3.2
1920–6
(91–97) 24
(8–68) 67
(24–187) 14
(8–25) 17
(9–33) 29
(13–65) 29
(13–62) 16
(9–28) 18
(11–32) 19
(10–37) 170
(54–533) 111
(49–254)
1927–36
(81–90) 13
(9–19) 34
(19–58) 38
(26–57) 57
(39–84) 27
(21–34) 26
(17–40) 14
(10–20) 19
(12–27) 20
(12–33) 93
(63–135) 101
(79–128)
1937–46
(71–80) 14
(8–23) 31
(18–54) 68
(39–118) 98
(64–149) 53
(41–68) 36
(23–55) 22
(13–35) 17
(11–26) 34
(23–50) 42
(25–69) 85
(55–133)
1947–56
(61–70) 11
(9–13) 19
(12–30) 29
(16–54) 59
(38–93) 36
(22–60) 59
(34–102) 30
(21–44) 18
(12–26) 19
(12–30) 47
(27–83) 73
(45–119)
1957–66
(51–60) 10
(10–10) 20
(13–32) 52
(37–72) 80
(51–124) 40
(28–58) 36
(25–53) 11
(9–13) 11
(9–13) 26
(14–47) 52
(40–67) 72
(45–116)
1967–76
(41–50) 11
(9–13) 23
(14–36) 41
(22–76) 109
(76–158) 27
(16–47) 16
(10–26) 11
(9–13) 13
(9–19) 24
(13–45) 40
(22–74) 38
(22–66)
1977–86
(31–40) 10
(10–10) 14
(9–21) 86
(55–137) 81
(47–138) 38
(22–65) 27
(15–48) 18
(11–30) 13
(10–17) 23
(14–37) 35
(19–65) 31
(16–60)
1987–96
(21–30) 10
(10–10) 15
(10–24) 41
(20–83) 34
(18–64) 46
(25–84) 43
(23–78) 13
(9–21) 11
(9–13) 35
(21–58) 46
(31–67) 47
(26–86)
1997–2006
(11–20) 15
(9–26) 31
(15–64 17
(10–27) 15
(10–22) 53
(29–99) 33
(20–55) 10
(10–10) 11
(9–14) 40
(23–70) 117
(54–256) 149
(58–379)
2007–17
(0–10) 18
(9–37) 37
(15–90) 11
(9–15) 12
(9–15) 11
(9–14) 10
(10–10) 10
(10–10) 10
(10–10) 10
(10–10) 70
(26–189) 88
(35–221)
All
(0–97) 13
(11–14)
25
(21–31) 33
(28–40) 44
(36–54) 33
(28–39) 28
(24–33) 14
(13–16) 13
(12–15) 23
(20–27) 60
(50–73) 71
58–86)

*Values expressed represent geometric mean virus neutralization titers of pooled serum samples per birth year (95% CI). Boldface indicates geometric mean VN titers of pooled serum samples per birth year. N. Am., North America.
†Human IAV that no longer circulates; TW86 is the presumed human precursor for human-like H1 swine IAVs in Europe; NC99 is the presumed human precursor for human-like H1 swine IAVs in North America; BR07 is a human seasonal IAV that circulated right before the influenza A(H1N1)pdm09 virus; the influenza A(H1N1)pdm09 virus, represented by CA09, is circulating in both humans and swine worldwide.
‡Age at the end of 2017.

Main Article

1Preliminary results from this study were presented at the Fourth International Symposium on Neglected Influenza Viruses, April 18–20, 2018, Brighton, United Kingdom; at the BELVIR conference, December 20, 2018, Brussels, Belgium; and at the 1918 Pandemic Conference, February 7–8, 2019, Ypres, Belgium.

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Page updated: August 18, 2020
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