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Volume 26, Number 9—September 2020
Research

Detection of H1 Swine Influenza A Virus Antibodies in Human Serum Samples by Age Group1

Elien Vandoorn, Isabel Leroux-Roels, Geert Leroux-Roels, Anna Parys, Amy Vincent, and Kristien Van ReethComments to Author 
Author affiliations: Ghent University, Merelbeke, Belgium (E. Vandoorn, A. Parys, K. Van Reeth); Ghent University and Ghent University Hospital, Ghent, Belgium (I. Leroux-Roels, G. Leroux-Roels); National Animal Disease Center, Ames, Iowa, USA (A. Vincent)

Main Article

Table 8

Spearman correlation coefficients between hemagglutination inhibition antibody titers against human and swine H1 influenza A viruses (upper right) and between virus neutralization antibody titers against human and swine H1 influenza A viruses (lower left)*

Virus strain
 Eurasian avian
Human seasonal
Classical swine
swG10
 swHK11
 TW86†
 swG12
 NC99†
 swAL16
 swIL10
 swOK13
 BR07†
 swOH07
 CA09
Europe 1C.2.1
 Asia 1C.2.3
 1B.1-like
 Europe 1B.1.2.1
 1B.2-like
 N. Am. 1B.2.2.1
 N. Am. 1B.2.2.2
 N. Am. 1B.2.2.2
 1B.2-like
 N. Am. 1A.3.3.3
 World 1A.3.3.2
swG10 – 0.68 NS 0.16 0.19 0.19 NS 0.26 0.18 0.56 0.55
swHK11
 0.63
 –
0.24
 0.26
 0.32
 0.31
 0.23
 0.43
 0.30
0.68
 0.63
TW86 NS NS – 0.84 0.52 0.43 0.21 0.35 0.35 0.25 0.26
swG12
 NS
 NS
0.77
 –
 0.42
 0.41
 0.23
 0.37
 0.28
0.30
 0.27
NC99 NS NS 0.46 0.37 – 0.69 0.42 0.43 0.75 0.36 0.36
swAL16 NS NS NS NS 0.71 – 0.53 0.38 0.58 0.43 0.39
swIL10 NS NS NS 0.37 0.39 0.52 – 0.37 0.45 0.30 0.26
swOK13
 NS
 NS
NS
 NS
 NS
 NS
 0.35
 –
 0.39
0.33
 0.34
BR07
 NS
 NS
NS
 NS
 0.76
 0.57
 NS
 NS
 –
0.30
 0.31
swOH07 0.55 0.67 NS NS NS NS NS NS NS – 0.86
CA09
 0.49
 0.62
NS
 NS
 NS
 NS
 NS
 NS
 NS
0.74
 –
*Viruses are ordered chronologically according to the year of circulation of the selected human test viruses TW86, NC99, BR07, and CA09; horizontal rules within table represent grouping of epidemiologically related human and swine influenza A viruses, with the oldest (ancestor) virus mentioned first. Complete isolate names are provided in Table 1. N. Am., North America; NS, not significant; –, not applicable.
†Human IAV that no longer circulates; TW86 is the presumed human precursor for human-like H1 swine IAVs in Europe; NC99 is the presumed human precursor for human-like H1 swine IAVs in North America; BR07 is a human seasonal IAV that circulated right before the influenza A(H1N1)pdm09 virus; the influenza A(H1N1)pdm09 virus, represented by CA09, is circulating in both humans and swine worldwide.

Main Article

1Preliminary results from this study were presented at the Fourth International Symposium on Neglected Influenza Viruses, April 18–20, 2018, Brighton, United Kingdom; at the BELVIR conference, December 20, 2018, Brussels, Belgium; and at the 1918 Pandemic Conference, February 7–8, 2019, Ypres, Belgium.

Page created: July 06, 2020
Page updated: August 18, 2020
Page reviewed: August 18, 2020
The conclusions, findings, and opinions expressed by authors contributing to this journal do not necessarily reflect the official position of the U.S. Department of Health and Human Services, the Public Health Service, the Centers for Disease Control and Prevention, or the authors' affiliated institutions. Use of trade names is for identification only and does not imply endorsement by any of the groups named above.
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