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Volume 26, Number 9—September 2020
Dispatch

Clinicopathologic and Immunohistochemical Findings from Autopsy of Patient with COVID-19, Japan

Takuya Adachi, Ja-Mun Chong, Noriko Nakajima, Masahiro Sano, Jun Yamazaki, Ippei Miyamoto, Haruka Nishioka, Hidetaka Akita, Yuko Sato, Michiyo Kataoka, Harutaka Katano, Minoru Tobiume, Tsuyoshi Sekizuka, Kentaro Itokawa, Makoto Kuroda, and Tadaki SuzukiComments to Author 
Author affiliations: Toshima Hospital, Tokyo, Japan (T. Adachi, J.-M. Chong, M. Sano, J. Yamazaki, I. Miyamoto, H. Nishioka, H. Akita); National Institute of Infectious Diseases, Tokyo, Japan (N. Nakajima, Y. Sato, M. Kataoka, H. Katano, M. Tobiume, T. Sekizuka, K. Itokawa, M. Kuroda, T. Suzuki)

Main Article

Table 1

Symptoms, signs, laboratory results, and treatment administered for an 84-year-old woman who died from coronavirus disease, by day of illness, cruise ship and Toshima Hospital, Tokyo, Japan, February 2020*

Characteristic Day of illness
Cruise ship
 Hospital
1 2 3 4 5 6 7 8 9 10 11 12 13 14 15 16
Symptom
Temperature, °C 38.8 38.5 38.9 38.3 37.9 37.5 37.1 37.2 37.5 37.7 36.9
Dyspnea† + + + + ++ ++ ++ ++ +++ +++ +++ +++ +++
SaO2, %
95–96
 90–95
 86–94
 84–92
 83–86
 79–84
 74–84
 66–79
Intervention
O2 (L/min) 2 5 15 15 15 15 15 15 15
ABPC/SBT * * * * *
MPSL, HYD * * * * * *
LPV/r * * *
Morphine
*
 *
 *
Blood test result
Leukocytes, 103/µL 3.7 4.2 12.4
PLT, 104/µL 13.4 14.0 22.8
AST, U/L 53 58 46
ALT, U/L 25 26 28
CRE, mg/dL 0.71 0.64 0.63
CRP, mg/dL 2.66 3.40 1.32

*ABPC/SBT, ampicillin/sulbactam; ALT, alanine aminotransferase; AST, aspartate aminotransferase; CRE, creatinine; CRP, C-reactive protein; HYD, hydrocortisone; LPV/r, lopinavir/ritonavir; MPSL, methylprednisolone; PLT, platelet; SaO2, oxygen saturation.
†Dyspnea severity indicated by +, mild; ++, moderate; +++, severe.

Main Article

Page created: May 15, 2020
Page updated: August 19, 2020
Page reviewed: August 19, 2020
The conclusions, findings, and opinions expressed by authors contributing to this journal do not necessarily reflect the official position of the U.S. Department of Health and Human Services, the Public Health Service, the Centers for Disease Control and Prevention, or the authors' affiliated institutions. Use of trade names is for identification only and does not imply endorsement by any of the groups named above.
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