Volume 26, Number 9—September 2020
Dispatch
Clinicopathologic and Immunohistochemical Findings from Autopsy of Patient with COVID-19, Japan
Takuya Adachi, Ja-Mun Chong, Noriko Nakajima, Masahiro Sano, Jun Yamazaki, Ippei Miyamoto, Haruka Nishioka, Hidetaka Akita, Yuko Sato, Michiyo Kataoka, Harutaka Katano, Minoru Tobiume, Tsuyoshi Sekizuka, Kentaro Itokawa, Makoto Kuroda, and Tadaki Suzuki
Table 2
Quantification of SARS-CoV-2 RNA in multiple specimens from an 84-year-old woman who died from coronavirus disease, Toshima Hospital, Tokyo, Japan, February 2020*
| Day of illness | Specimen type or site | SARS-CoV-2 RNA | SARS-CoV-2, copies/reaction | GAPDH, copies/reaction | SARS-CoV-2 to GAPDH, ratio |
|---|---|---|---|---|---|
| Day 8 (admission) | Serum, copies/μL | 2.7 × 101 | |||
| Day 10 | 6.2 × 101 | ||||
| Day 13 | 2.8 × 102 | ||||
| Day 16 (autopsy) | Whole blood, copies/μL | 1.6 × 102 | |||
| Urine, copies/μL | UDL | ||||
| Feces, copies/μL | 1.2 × 102 | ||||
| Swabs, copies in 1 μL medium) | |||||
| Nasopharynx | 2.9 × 103 | ||||
| Trachea | 1.5 × 102 | ||||
| Right bronchus | 6.6 × 104 | ||||
| Left bronchus | 1.3 × 102 | ||||
| Rectum | 3.7 × 101 | ||||
| Frozen tissues | |||||
| Pharynx | 83 | 2,670 | 3.1 × 10–2 | ||
| Tonsils | UDL | 3,730 | NA | ||
| Epiglottis | 43 | 13,000 | 3.3 × 10–3 | ||
| Trachea | UDL | 145 | NA | ||
| Right bronchus | 840 | 421 | 2.0 × 100 | ||
| Right lung | |||||
| Upper, S1/S2 | 76,600 | 1,570 | 4.9 × 101 | ||
| Upper, S3 | 584 | 82 | 7.1 × 100 | ||
| Middle, S5 | 11,900 | 3,000 | 4.0 × 100 | ||
| Lower, S6 | 37,100 | 1,230 | 3.0 × 101 | ||
| Lower, S8/S9 | 21,500 | 1,860 | 1.2 × 101 | ||
| Lower, S7/S10 | 17,100 | 221 | 7.7 × 101 | ||
| Left bronchus | 67 | 93 | 7.2 × 10–1 | ||
| Left lung | |||||
| Upper, S1+2 | 56,500 | 2,300 | 2.5 × 101 | ||
| Upper, S3 | 26,300 | 12,600 | 2.1 × 100 | ||
| Upper, S4/S5 | 6,260 | 1,530 | 4.1 × 100 | ||
| Lower, S6 | 80,500 | 1,840 | 4.4 × 101 | ||
| Lower, S8/S9 | 1,000 | 325 | 3.1 × 100 | ||
| Lower, S10 | 22,900 | 977 | 2.3 × 101 | ||
| Heart | UDL | 64,800 | NA | ||
| Liver | 57 | 104,000 | 5.5 × 10–4 | ||
| Kidney | UDL | 5,910 | NA | ||
| Spleen | 259 | 444,000 | 6.0 × 10–4 | ||
| Pancreas | UDL | 3,690 | NA | ||
| Colon | 35 | 5, 030 | 7.0 × 10–3 |
*GAPDH, glyceraldehyde-3-phosphate dehydrogenase; NA, not applicable; S, segment; SARS-CoV-2; severe acute respiratory syndrome coronavirus 2; UDL, under detection limit (<10 copies/reaction).
Page created: May 15, 2020
Page updated: August 19, 2020
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