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Volume 27, Number 1—January 2021
Research

Intrafamilial Exposure to SARS-CoV-2 Associated with Cellular Immune Response without Seroconversion, France

Floriane Gallais, Aurélie Velay, Charlotte Nazon, Marie-Josée Wendling, Marialuisa Partisani, Jean Sibilia, Sophie Candon, and Samira Fafi-KremerComments to Author 
Author affiliations: Strasbourg University Hospital, Strasbourg, France (F. Gallais, A. Velay, C. Nazon, M.-J. Wendling, M. Partisani, J. Sibilia, S. Fafi-Kremer); Strasbourg University, Strasbourg (F. Gallais, A. Velay, C. Nazon, M.-J. Wendling, J. Sibilia, S. Fafi-Kremer); Rouen University Hospital, Rouen, France (S. Candon)

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Figure 4

Correlation of the T-cell responses against spike glycoprotein antigens of SARS-CoV-2 and HCoVs 229E and OC43 in study of intrafamilial exposure to SARS-CoV-2, France. Means of spot counts of interferon gamma–producing T cells per 1 million CD3+ cells in response to peptide pools spanning the N terminal (S1) and the C-terminal (S2) regions of spike glycoproteins of SARS-CoV-2 compared with HCoV-229E (A) and HCoV-OC43 (B) in 11 confirmed coronavirus disease cases (index patients), their seronegative partners (contacts), and 10 healthy blood donor controls. HCoV, human coronavirus; SARS-CoV-2, severe acute respiratory syndrome coronavirus 2.

Figure 4. Correlation of the T-cell responses against spike glycoprotein antigens of SARS-CoV-2 and HCoVs 229E and OC43 in study of intrafamilial exposure to SARS-CoV-2, France. Means of spot counts of interferon gamma–producing T cells per 1 million CD3+ cells in response to peptide pools spanning the N terminal (S1) and the C-terminal (S2) regions of spike glycoproteins of SARS-CoV-2 compared with HCoV-229E (A) and HCoV-OC43 (B) in 11 confirmed coronavirus disease cases (index patients), their seronegative partners (contacts), and 10 healthy blood donor controls. HCoV, human coronavirus; SARS-CoV-2, severe acute respiratory syndrome coronavirus 2.

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Page created: September 29, 2020
Page updated: December 21, 2020
Page reviewed: December 21, 2020
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