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Volume 27, Number 10—October 2021
Synopsis

Severe Acute Respiratory Syndrome Coronavirus 2 and Pregnancy Outcomes According to Gestational Age at Time of Infection

Dominique A. Badr, Olivier Picone, Elisa Bevilacqua, Andrew Carlin, Federica Meli, Jeanne Sibiude, Jérémie Mattern, Jean-François Fils, Laurent Mandelbrot, Antonio Lanzone, Danièle De Luca, Jacques C. JaniComments to Author , and Alexandre J. Vivanti
Author affiliations: University Hospital Brugmann, Brussels, Belgium (D.A. Badr, A. Carlin, J.C. Jani); Université Libre de Bruxelles, Brussels (D.A. Badr, A. Carlin, J.C. Jani); Louis Mourier Hospital, AP-HP, Colombes, France (O. Picone, J. Sibuide, L. Mandelbrot); Université de Paris, Paris, France (O. Picone, J. Sibuide, L. Mandelbrot); Inserm IAME-U1137, Paris (O. Picone, J. Sibuide, L. Mandelbrot); Groupe de Recherche sur les Infections pendant la Grossesse (GRIG), Velizy, France (O. Picone, J. Sibuide, L. Mandelbrot, A.J. Vivanti); Gemelli University Polyclinic Foundation, Rome, Italy (E. Bevilacqua, F. Melli, A. Lanzone); Antoine Béclère Hospital, AP-HP, Clamart, France (J. Mattern, A.J. Vivanti, D. De Luca); Paris Saclay University, Paris (J. Mattern, D. De Luca, A.J. Vivanti); Ars Statistica, Nivelles, Belgium (J.-F. Fils); Catholic University Sacro Cuore, Rome (A. Lanzone)

Main Article

Table 3

Obstetric outcomes in PregOutCOV study of pregnancy outcomes in Europe according to gestational age at time of infection with severe acute respiratory syndrome coronavirus 2*

Outcome Unexposed, n = 10,532 Exposed, n = 393 p value ASD
Primary outcome†
Composite adverse obstetric outcome
 19.25
 22.75
 <0.001
 8.62
Secondary outcome‡
Preeclampsia, eclampsia, or HELLP syndrome 1.89 2.44 0.004 3.78
Pregnancy loss at <24 weeks 1.06 0.71 0.034 3.73
Pregnancy loss at >24 weeks 1.54 1.19 0.060 2.97
Delivery at <32 weeks 3.18 3.63 0.052 2.51
Delivery at <37 weeks 8.90 12.22 <0.001 10.71
Spontaneous delivery at <37 weeks 5.65 4.96 0.056 2.86
Caesarean delivery 24.68 26.63 0.002 4.17
Unscheduled caesarean delivery 12.27 13.87 <0.001 4.73
Postpartum hemorrhage 9.23 12.57 <0.001 10.74
DVT or PE 0.06 0.53 <0.001 8.77

*Values are % pregnant women except as indicated. ASD, absolute standardized difference; DVT, deep vein thrombosis; HELLP, hemolysis, elevated liver enzymes, low platelet count; PE, pulmonary embolism. †Significant statistical difference: p < 0.05. ‡Significant statistical difference: p < 0.005 (Bonferroni correction).

Main Article

Page created: August 02, 2021
Page updated: September 19, 2021
Page reviewed: September 19, 2021
The conclusions, findings, and opinions expressed by authors contributing to this journal do not necessarily reflect the official position of the U.S. Department of Health and Human Services, the Public Health Service, the Centers for Disease Control and Prevention, or the authors' affiliated institutions. Use of trade names is for identification only and does not imply endorsement by any of the groups named above.
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