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Volume 27, Number 10—October 2021

Severe Acute Respiratory Syndrome Coronavirus 2 and Pregnancy Outcomes According to Gestational Age at Time of Infection

Dominique A. Badr, Olivier Picone, Elisa Bevilacqua, Andrew Carlin, Federica Meli, Jeanne Sibiude, Jérémie Mattern, Jean-François Fils, Laurent Mandelbrot, Antonio Lanzone, Danièle De Luca, Jacques C. JaniComments to Author , and Alexandre J. Vivanti
Author affiliations: University Hospital Brugmann, Brussels, Belgium (D.A. Badr, A. Carlin, J.C. Jani); Université Libre de Bruxelles, Brussels (D.A. Badr, A. Carlin, J.C. Jani); Louis Mourier Hospital, AP-HP, Colombes, France (O. Picone, J. Sibuide, L. Mandelbrot); Université de Paris, Paris, France (O. Picone, J. Sibuide, L. Mandelbrot); Inserm IAME-U1137, Paris (O. Picone, J. Sibuide, L. Mandelbrot); Groupe de Recherche sur les Infections pendant la Grossesse (GRIG), Velizy, France (O. Picone, J. Sibuide, L. Mandelbrot, A.J. Vivanti); Gemelli University Polyclinic Foundation, Rome, Italy (E. Bevilacqua, F. Melli, A. Lanzone); Antoine Béclère Hospital, AP-HP, Clamart, France (J. Mattern, A.J. Vivanti, D. De Luca); Paris Saclay University, Paris (J. Mattern, D. De Luca, A.J. Vivanti); Ars Statistica, Nivelles, Belgium (J.-F. Fils); Catholic University Sacro Cuore, Rome (A. Lanzone)

Main Article

Table 3

Obstetric outcomes in PregOutCOV study of pregnancy outcomes in Europe according to gestational age at time of infection with severe acute respiratory syndrome coronavirus 2*

Outcome Unexposed, n = 10,532 Exposed, n = 393 p value ASD
Primary outcome†
Composite adverse obstetric outcome
Secondary outcome‡
Preeclampsia, eclampsia, or HELLP syndrome 1.89 2.44 0.004 3.78
Pregnancy loss at <24 weeks 1.06 0.71 0.034 3.73
Pregnancy loss at >24 weeks 1.54 1.19 0.060 2.97
Delivery at <32 weeks 3.18 3.63 0.052 2.51
Delivery at <37 weeks 8.90 12.22 <0.001 10.71
Spontaneous delivery at <37 weeks 5.65 4.96 0.056 2.86
Caesarean delivery 24.68 26.63 0.002 4.17
Unscheduled caesarean delivery 12.27 13.87 <0.001 4.73
Postpartum hemorrhage 9.23 12.57 <0.001 10.74
DVT or PE 0.06 0.53 <0.001 8.77

*Values are % pregnant women except as indicated. ASD, absolute standardized difference; DVT, deep vein thrombosis; HELLP, hemolysis, elevated liver enzymes, low platelet count; PE, pulmonary embolism. †Significant statistical difference: p < 0.05. ‡Significant statistical difference: p < 0.005 (Bonferroni correction).

Main Article

Page created: August 02, 2021
Page updated: September 19, 2021
Page reviewed: September 19, 2021
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