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Volume 27, Number 10—October 2021

Severe Acute Respiratory Syndrome Coronavirus 2 and Pregnancy Outcomes According to Gestational Age at Time of Infection

Dominique A. Badr, Olivier Picone, Elisa Bevilacqua, Andrew Carlin, Federica Meli, Jeanne Sibiude, Jérémie Mattern, Jean-François Fils, Laurent Mandelbrot, Antonio Lanzone, Danièle De Luca, Jacques C. JaniComments to Author , and Alexandre J. Vivanti
Author affiliations: University Hospital Brugmann, Brussels, Belgium (D.A. Badr, A. Carlin, J.C. Jani); Université Libre de Bruxelles, Brussels (D.A. Badr, A. Carlin, J.C. Jani); Louis Mourier Hospital, AP-HP, Colombes, France (O. Picone, J. Sibuide, L. Mandelbrot); Université de Paris, Paris, France (O. Picone, J. Sibuide, L. Mandelbrot); Inserm IAME-U1137, Paris (O. Picone, J. Sibuide, L. Mandelbrot); Groupe de Recherche sur les Infections pendant la Grossesse (GRIG), Velizy, France (O. Picone, J. Sibuide, L. Mandelbrot, A.J. Vivanti); Gemelli University Polyclinic Foundation, Rome, Italy (E. Bevilacqua, F. Melli, A. Lanzone); Antoine Béclère Hospital, AP-HP, Clamart, France (J. Mattern, A.J. Vivanti, D. De Luca); Paris Saclay University, Paris (J. Mattern, D. De Luca, A.J. Vivanti); Ars Statistica, Nivelles, Belgium (J.-F. Fils); Catholic University Sacro Cuore, Rome (A. Lanzone)

Main Article

Table 4

Neonatal outcomes in PregOutCOV study of pregnancy outcomes in Europe according to gestational age at time of infection with severe acute respiratory syndrome coronavirus 2*

Outcome Unexposed, n = 10,370 Exposed, n = 388 p value ASD
Primary outcome†
Composite adverse neonatal outcome
Secondary outcome†
Small for gestational age 10.89 9.39 <0.001 4.98
Large for gestational age 6.53 5.60 0.0029 3.87
Fetal distress 8.74 10.95 <0.001 7.44
Neonatal death 0.32 0.14 <0.001 3.66
Birthweight, g (SD) 3228.00 (±579.34) 3128.90 (±602.93) <0.001 16.76
NICU admission 7.76 13.09 <0.001 17.49
Respiratory distress 7.10 7.86 0.0297 2.89
APGAR <7 at 5 min 2.58 4.01 <0.001 8.03
Umbilical artery pH 7.25 ± 0.08 7.25 ± 0.07 <0.001 11.12

*Values are % pregnant women except as indicated. ASD, absolute standardized difference; NICU, neonatal intensive care unit. †Statistically significant difference: p<0.05. ‡Statistically significant difference: p<0.005 (Bonferroni correction).

Main Article

Page created: August 02, 2021
Page updated: September 19, 2021
Page reviewed: September 19, 2021
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