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Volume 27, Number 10—October 2021
Synopsis

Severe Acute Respiratory Syndrome Coronavirus 2 and Pregnancy Outcomes According to Gestational Age at Time of Infection

Dominique A. Badr, Olivier Picone, Elisa Bevilacqua, Andrew Carlin, Federica Meli, Jeanne Sibiude, Jérémie Mattern, Jean-François Fils, Laurent Mandelbrot, Antonio Lanzone, Danièle De Luca, Jacques C. JaniComments to Author , and Alexandre J. Vivanti
Author affiliations: University Hospital Brugmann, Brussels, Belgium (D.A. Badr, A. Carlin, J.C. Jani); Université Libre de Bruxelles, Brussels (D.A. Badr, A. Carlin, J.C. Jani); Louis Mourier Hospital, AP-HP, Colombes, France (O. Picone, J. Sibuide, L. Mandelbrot); Université de Paris, Paris, France (O. Picone, J. Sibuide, L. Mandelbrot); Inserm IAME-U1137, Paris (O. Picone, J. Sibuide, L. Mandelbrot); Groupe de Recherche sur les Infections pendant la Grossesse (GRIG), Velizy, France (O. Picone, J. Sibuide, L. Mandelbrot, A.J. Vivanti); Gemelli University Polyclinic Foundation, Rome, Italy (E. Bevilacqua, F. Melli, A. Lanzone); Antoine Béclère Hospital, AP-HP, Clamart, France (J. Mattern, A.J. Vivanti, D. De Luca); Paris Saclay University, Paris (J. Mattern, D. De Luca, A.J. Vivanti); Ars Statistica, Nivelles, Belgium (J.-F. Fils); Catholic University Sacro Cuore, Rome (A. Lanzone)

Main Article

Table 2

Baseline characteristics before and after covariate matching of the mothers of the 10,758 live neonates in Europe included in final analysis (after removing 167 patients with pregnancy losses) in PregOutCOV study of pregnancy outcomes according to gestational age at time of infection with severe acute respiratory syndrome coronavirus 2*

Characteristic
 Before matching
After matching
Unexposed, n = 1,0370
 Exposed, n = 388
 ASD†
 Unexposed, n = 10,370
 Exposed, n = 388
 ASD‡
Mean age, y (SD)
 33.11 (+5.43)
 33.31 (+5.61)
 3.67
33.11 (+5.42)
 33.13 (+5.55)
 0.44
Origin
Europe, Middle East, North Africa 78.52 77.58 2.29 78.49 78.51 0.07
Sub-Saharan Africa, Caribbean 13.63 17.27 10.08 13.76 13.75 0.04
Not mentioned by the patient 6.85 3.87 13.29 6.73 6.76 0.11
Not available
 1.00
 1.29
 2.75
1.02
 0.98
 0.41
Prepregnancy BMI, kg/m2 (SD) 25.65 (+5.99) 26.72 (+5.92) 17.83 25.71 (+6.05) 25.70 (+5.31) 0.11
Multiparity 53.78 59.28 11.10 53.96 53.96 0.01
Smoking 12.10 11.34 2.36 12.10 12.06 0.12
Chronic hypertension 1.26 1.29 0.24 1.26 1.27 0.10

*Values are % pregnant women except as indicated. ASD, absolute standardized difference; BMI, body mass index. †ASDs before matching show heterogeneity between the exposed and unexposed groups. ‡ASDs after matching show a balance between the exposed and unexposed groups.

Main Article

Page created: August 02, 2021
Page updated: September 19, 2021
Page reviewed: September 19, 2021
The conclusions, findings, and opinions expressed by authors contributing to this journal do not necessarily reflect the official position of the U.S. Department of Health and Human Services, the Public Health Service, the Centers for Disease Control and Prevention, or the authors' affiliated institutions. Use of trade names is for identification only and does not imply endorsement by any of the groups named above.
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