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Volume 27, Number 11—November 2021
Dispatch

Genetically Divergent Highly Pathogenic Avian Influenza A(H5N8) Viruses in Wild Birds, Eastern China

Guimei He, Le Ming, Xiang Li, Yuhe Song, Ling Tang, Min Ma, Jie CuiComments to Author , and Tianhou WangComments to Author 
Author affiliations: East China Normal University, Shanghai, China (G. He, L. Ming, L. Tang, M. Ma, T. Wang); CAS Key Laboratory of Molecular Virology & Immunology, Institut Pasteur, Center for Biosafety Mega-Science, Chinese Academy of Sciences, Shanghai (X. Li, Y. Song, J. Cui)

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Figure

Phylogenetic tree of highly pathogenic avian influenza A(H5N8) viruses isolated in Shanghai, China during 2020 (red text) and reference sequences from GISAID (https://www.gisaid.org). Tree was based on hemagglutinin gene segment; it was constructed using IQ-TREE (13) with 1,000 bootstrap replicates. Yellow shading indicates subclade 2.3.4.4b strains. Pink and blue shading indicate 2 sublineages of subclade 2.3.4.4b. Numbers to the left of node indicate bootstrap values. Scale bars indicate average number of nucleotide substitutions per site.

Figure. Phylogenetic tree of highly pathogenic avian influenza A(H5N8) viruses isolated in Shanghai, China during 2020 (red text) and reference sequences from GISAID (https://www.gisaid.org). Tree was based on hemagglutinin gene segment; it was constructed using IQ-TREE (13) with 1,000 bootstrap replicates. Yellow shading indicates subclade 2.3.4.4b strains. Pink and blue shading indicate 2 sublineages of subclade 2.3.4.4b. Numbers to the left of node indicate bootstrap values. Scale bars indicate average number of nucleotide substitutions per site.

Main Article

References
  1. Gu  M, Liu  W, Cao  Y, Peng  D, Wang  X, Wan  H, et al. Novel reassortant highly pathogenic avian influenza (H5N5) viruses in domestic ducks, China. Emerg Infect Dis. 2011;17:10603. DOIPubMedGoogle Scholar
  2. Wu  H, Peng  X, Xu  L, Jin  C, Cheng  L, Lu  X, et al. Novel reassortant influenza A(H5N8) viruses in domestic ducks, eastern China. Emerg Infect Dis. 2014;20:13158. DOIPubMedGoogle Scholar
  3. Lee  YJ, Kang  HM, Lee  EK, Song  BM, Jeong  J, Kwon  YK, et al. Novel reassortant influenza A(H5N8) viruses, South Korea, 2014. Emerg Infect Dis. 2014;20:10879. DOIPubMedGoogle Scholar
  4. Lee  DH, Torchetti  MK, Winker  K, Ip  HS, Song  CS, Swayne  DE. Intercontinental spread of Asian-origin H5N8 to North America through Beringia by migratory birds. J Virol. 2015;89:65214. DOIPubMedGoogle Scholar
  5. Bouwstra  R, Heutink  R, Bossers  A, Harders  F, Koch  G, Elbers  A. Full-genome sequence of influenza A(H5N8) virus in poultry linked to sequences of strains from Asia, the Netherlands, 2014. Emerg Infect Dis. 2015;21:8724. DOIPubMedGoogle Scholar
  6. Napp  S, Majó  N, Sánchez-Gónzalez  R, Vergara-Alert  J. Emergence and spread of highly pathogenic avian influenza A(H5N8) in Europe in 2016-2017. Transbound Emerg Dis. 2018;65:121726. DOIPubMedGoogle Scholar
  7. Lewis  NS, Banyard  AC, Whittard  E, Karibayev  T, Al Kafagi  T, Chvala  I, et al. Emergence and spread of novel H5N8, H5N5 and H5N1 clade 2.3.4.4 highly pathogenic avian influenza in 2020. Emerg Microbes Infect. 2021;10:14851. DOIPubMedGoogle Scholar
  8. Isoda  N, Twabela  AT, Bazarragchaa  E, Ogasawara  K, Hayashi  H, Wang  ZJ, et al. Re-invasion of H5N8 high pathogenicity avian influenza virus clade 2.3.4.4b in Hokkaido, Japan, 2020. Viruses. 2020;12:1439. DOIPubMedGoogle Scholar
  9. Jeong  S, Lee  DH, Kwon  JH, Kim  YJ, Lee  SH, Cho  AY, et al. Highly pathogenic avian influenza clade 2.3.4.4b subtype H5N8 virus isolated from mandarin duck in South Korea, 2020. Viruses. 2020;12:1389. DOIPubMedGoogle Scholar
  10. Baek  YG, Lee  YN, Lee  DH, Shin  JI, Lee  JH, Chung  DH, et al. Multiple reassortants of H5N8 clade 2.3.4.4b highly pathogenic avian influenza viruses detected in South Korea during the winter of 2020–2021. Viruses. 2021;13:490. DOIPubMedGoogle Scholar
  11. Li  X, Lv  X, Li  Y, Peng  P, Zhou  R, Qin  S, et al. Highly pathogenic avian influenza A (H5N8) virus in swans, China, 2020. Emerg Infect Dis. 2021;27:17324. DOIPubMedGoogle Scholar
  12. Tang  L, Tang  W, Ming  L, Gu  J, Qian  K, Li  X, et al. Characterization of avian influenza virus H10–H12 subtypes isolated from wild birds in Shanghai, China from 2016 to 2019. Viruses. 2020;12:1085. DOIPubMedGoogle Scholar
  13. Minh  BQ, Schmidt  HA, Chernomor  O, Schrempf  D, Woodhams  MD, von Haeseler  A, et al. IQ-TREE 2: new models and efficient methods for phylogenetic inference in the genomic era. Mol Biol Evol. 2020;37:15304. DOIPubMedGoogle Scholar
  14. Świętoń  E, Fusaro  A, Shittu  I, Niemczuk  K, Zecchin  B, Joannis  T, et al. Sub-Saharan Africa and Eurasia ancestry of reassortant highly pathogenic avian influenza A(H5N8) virus, Europe, December 2019. Emerg Infect Dis. 2020;26:155761. DOIPubMedGoogle Scholar
  15. Global Consortium for H5N8 and Related Influenza Viruses. Role for migratory wild birds in the global spread of avian influenza H5N8. Science. 2016;354:2137. DOIPubMedGoogle Scholar

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Page updated: October 19, 2021
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