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Volume 27, Number 11—November 2021

Dispatch

Correlation of SARS-CoV-2 Subgenomic RNA with Antigen Detection in Nasal Midturbinate Swab Specimens

Katherine Immergluck1, Mark D. Gonzalez, Jennifer K. Frediani, Joshua M. Levy, Janet Figueroa, Anna Wood, Beverly B. Rogers, Jared O’Neal, Roger Elias-Marcellin, Allie Suessmith, Julie Sullivan, Raymond F. Schinazi, Ahmed Babiker, Anne Piantadosi, Miriam B. Vos, Greg S. Martin, Wilbur A. Lam, and Jesse J. WaggonerComments to Author 
Author affiliations: Emory University, Atlanta, Georgia, USA (K. Immergluck, M.D. Gonzalez, J.K. Frediani, J.M. Levy, J. Figueroa, A. Wood, B.B. Rogers, J. O’Neal, R. Elias-Marcellin, A. Suessmith, J. Sullivan, R.F. Schinazi, A. Babiker, A. Piantadosi, M.B. Vos, G.S. Martin, W.A. Lam, J.J. Waggoner); The Atlanta Center for Microsystems-Engineered Point-of-Care Technologies, Atlanta (K. Immergluck, M.D. Gonzalez, J.K. Frediani, J.M. Levy, J. Figueroa, A. Wood, B.B. Rogers, J. O’Neal, A. Suessmith, J. Sullivan, R.F. Schinazi, M.B. Vos, G.S. Martin, W.A. Lam, J.J. Waggoner); Children’s Healthcare of Atlanta, Atlanta (M.D. Gonzalez, M.B. Vos)

Main Article

Table 2

Correlation of SARS-CoV-2 subgenomic RNA with nucleocapsid detection in NP specimens from study participants analyzed for SARS-CoV-2 subgenomic RNA, Atlanta, Georgia, USA *

Variable Overall, n = 39 Antigen positive, n = 20 Antigen negative, n = 19 p value
Mean age, y (SD) 8.6 (5.8) 9.8 (5.6) 7.4 (5.8) 0.148
Female sex
 16 (41.0)
 8 (40.0)
 8 (42.1)
 0.894
Mean days after symptom onset (SD)† 3.7 (2.2) 3.0 (1.4) 4.5 (2.7) 0.227
Repeat NP swab specimen, rRT-PCR positive
 36 (92.3)
 20 (100.0)
 16 (84.2)
 0.106
Race
White 26 (66.67) 13 (65.0) 13 (68.42) 0.077
Black/African American 6 (15.38) 3 (15.0) 3 (15.79) NA
Asian 4 (10.26) 4 (20.0) 0 NA
Biracial
 3 (7.69)
 0
 3 (15.79)
 NA
Hispanic ethnicity 19 (48.72) 6 (30.0) 13 (68.42) 0.016

*Values are no. (%) unless indicated otherwise. NA, not available; NP, nasopharyngeal; rRT-PCR, real-time reverse transcription PCR; SARS-CoV-2, severe acute respiratory syndrome coronavirus 2. †Day sample was collected. One participant was asymptomatic (did not report symptoms in the past 14 days).

Main Article

1Current affiliation: Pomona College, Claremont, California, USA.

Page created: August 18, 2021
Page updated: October 19, 2021
Page reviewed: October 19, 2021
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