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Volume 28, Number 1—January 2022
Research

Systematic Genomic and Clinical Analysis of Severe Acute Respiratory Syndrome Coronavirus 2 Reinfections and Recurrences Involving the Same Strain

Cristina Rodríguez-Grande, Luis Alcalá, Agustín Estévez, Pedro J. Sola-Campoy, Sergio Buenestado-Serrano, Carolina Martínez-Laperche, Víctor Manuel de la Cueva, Roberto Alonso, Cristina Andrés-Zayas, Javier Adán-Jiménez, Carmen Losada, Carla Rico-Luna, Iñaki Comas, Fernando González-Candelas, Pilar Catalán, Patricia Muñoz, Laura Pérez-Lago1, Darío García de Viedma1Comments to Author , and on behalf of the Gregorio Marañón Microbiology-ID COVID 19 Study Group2
Author affiliations: Gregorio Marañón General University Hospital, Madrid, Spain (C. Rodríguez-Grande, L. Alcalá, A. Estévez, P.J. Sola-Campoy, S. Buenestado-Serrano, C. Martínez-Laperche, V.M. de la Cueva, R. Alonso, C. Andrés-Zayas, J. Adán-Jiménez, C. Losada, C. Rico-Luna, P. Catalán, P. Muñoz, L. Pérez-Lago, D. Garcia de Viedma); Instituto de Investigación Sanitaria Gregorio Marañón, Madrid (C. Rodríguez-Grande, L. Alcalá, A. Estévez, P.J. Sola-Campoy, S. Buenestado-Serrano, C. Martínez-Laperche, V.M. de la Cueva, R. Alonso, C. Andrés-Zayas, J. Adán-Jiménez, C. Losada, C. Rico-Luna, P. Catalán, P. Muñoz, L. Pérez-Lago, D. García de Viedma); CIBER Enfermedades Respiratorias, Madrid (L. Alcalá, R. Alonso, P. Catalán, P. Muñoz, D. García de Viedma); Instituto de Biomedicina de Valencia-CSIC, Valencia, Spain (I. Comas); CIBER Salud Pública, Madrid (I. Comas, F. González-Candelas); J; oint Research Unit “Infection and Public Health” FISABIO-University of Valencia, Institute for Integrative Systems Biology, Valencia (F. González-Candelas); Universidad Complutense de Madrid, Madrid (P. Muñoz)

Main Article

Table 1

Patient data and characteristics for both episodes of SARS-CoV-2 infection in recurrences involving the same strain, Madrid, Spain, March 2020–March 2021*

Pt Age, y/sex Underlying conditions PCR date, 1st/2nd episode PCR Ct value–N2 gene, 1st/2nd episode Interinfection period, d Symptoms, 1st/2nd episode† Serologic results, 1st/2nd episode (AU/mL) SARS-CoV-2 variant, 2nd episode
1 68/M HT 2020 Aug 12/2020 Dec 4 15/28 114 Asymptomatic/ asymptomatic + (56.8)/+ (76.8) Z.1
2 70/F HBP, obesity 2020 Mar 25/2020 Jun 10 31/27 77 Bilateral pneumonia/ dyspnoea NA/+ (1,967.1) A.5
3 93/F HBP, CKD 2020 Apr 17/2020 Jun 11 31/19 55 Diarrhea/NA –/NA A.5

4

39/F

BMT

2020 Mar 10/2020 Jun 19

17/27

101

Bilateral pneumonia/ diarrhea, fever

+ (415.4)/+ (636.3)

A.5

*BMT, bone marrow transplant; CKD, chronic kidney disease; HBP, high blood pressure; HT, heart transplant; N2, nucleocapsid; NA, not available; Pt, patient; SARS-CoV-2, severe acute respiratory syndrome coronavirus 2. †The definition of the severity of the patients has been organized according to the following criteria: Mild—general malaise, cough, diarrhea, headache, fever, anosmia, dysgeusia, myalgia, rhinorrhea; moderate—previous symptoms plus dyspnea, mild respiratory failure, or unilateral pneumonia, severe—previous symptoms plus bilateral pneumonia.

Main Article

1These senior authors contributed equally to this article.

2Members of the Gregorio Marañón Microbiology-ID COVID 19 Study Group are listed at the end of this article.

Page created: November 04, 2021
Page updated: December 20, 2021
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