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Volume 28, Number 1—January 2022
Research

Systematic Genomic and Clinical Analysis of Severe Acute Respiratory Syndrome Coronavirus 2 Reinfections and Recurrences Involving the Same Strain

Cristina Rodríguez-Grande, Luis Alcalá, Agustín Estévez, Pedro J. Sola-Campoy, Sergio Buenestado-Serrano, Carolina Martínez-Laperche, Víctor Manuel de la Cueva, Roberto Alonso, Cristina Andrés-Zayas, Javier Adán-Jiménez, Carmen Losada, Carla Rico-Luna, Iñaki Comas, Fernando González-Candelas, Pilar Catalán, Patricia Muñoz, Laura Pérez-Lago1, Darío García de Viedma1Comments to Author , and on behalf of the Gregorio Marañón Microbiology-ID COVID 19 Study Group2
Author affiliations: Gregorio Marañón General University Hospital, Madrid, Spain (C. Rodríguez-Grande, L. Alcalá, A. Estévez, P.J. Sola-Campoy, S. Buenestado-Serrano, C. Martínez-Laperche, V.M. de la Cueva, R. Alonso, C. Andrés-Zayas, J. Adán-Jiménez, C. Losada, C. Rico-Luna, P. Catalán, P. Muñoz, L. Pérez-Lago, D. Garcia de Viedma); Instituto de Investigación Sanitaria Gregorio Marañón, Madrid (C. Rodríguez-Grande, L. Alcalá, A. Estévez, P.J. Sola-Campoy, S. Buenestado-Serrano, C. Martínez-Laperche, V.M. de la Cueva, R. Alonso, C. Andrés-Zayas, J. Adán-Jiménez, C. Losada, C. Rico-Luna, P. Catalán, P. Muñoz, L. Pérez-Lago, D. García de Viedma); CIBER Enfermedades Respiratorias, Madrid (L. Alcalá, R. Alonso, P. Catalán, P. Muñoz, D. García de Viedma); Instituto de Biomedicina de Valencia-CSIC, Valencia, Spain (I. Comas); CIBER Salud Pública, Madrid (I. Comas, F. González-Candelas); J; oint Research Unit “Infection and Public Health” FISABIO-University of Valencia, Institute for Integrative Systems Biology, Valencia (F. González-Candelas); Universidad Complutense de Madrid, Madrid (P. Muñoz)

Main Article

Figure 1

Flow diagram of the analysis and selection criteria for severe acute respiratory syndrome coronavirus 2 re-positive cases, Madrid, Spain, March 2020–March 2021. Re-positive cases were those that had 2 sequential positive RT-PCR tests taken >45 days apart with >1 negative RT-PCRs between the positive tests. Ct, cycle threshold; SNP, single-nucleotide polymorphism; STR, short tandem repeat; VOC, variant of concern; VOI, variant of interest; WGS, whole-genome sequencing.

Figure 1. Flow diagram of the analysis and selection criteria for severe acute respiratory syndrome coronavirus 2 re-positive cases, Madrid, Spain, March 2020–March 2021. Re-positive cases were those that had 2 sequential positive RT-PCR tests taken >45 days apart with >1 negative RT-PCRs between the positive tests. Ct, cycle threshold; SNP, single-nucleotide polymorphism; STR, short tandem repeat; VOC, variant of concern; VOI, variant of interest; WGS, whole-genome sequencing.

Main Article

1These senior authors contributed equally to this article.

2Members of the Gregorio Marañón Microbiology-ID COVID 19 Study Group are listed at the end of this article.

Page created: November 04, 2021
Page updated: December 20, 2021
Page reviewed: December 20, 2021
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