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Volume 28, Number 10—October 2022
Research

Plasmodium falciparum pfhrp2 and pfhrp3 Gene Deletions and Relatedness to Other Global Isolates, Djibouti, 2019–2020

Eric Rogier1Comments to Author , Jessica N. McCaffery1, Mohamed Ali Mohamed, Camelia Herman, Doug Nace, Rachel Daniels, Naomi Lucchi, Sophie Jones, Ira Goldman, Michael Aidoo, Qin Cheng, Edie A. Kemenang, Venkatachalam Udhayakumar, and Jane Cunningham
Author affiliations: Centers for Disease Control and Prevention, Atlanta, Georgia, USA (E. Rogier, J.N. McCaffery, C. Herman, D. Nace, N. Lucchi, S. Jones, I. Goldman, M. Aidoo, V. Udhayakumar); Oak Ridge Institute for Science and Education, Oak Ridge, Tennessee, USA (J.N. McCaffery); Hôpital Général Peltier, Djibouti City, Djibouti (M.A. Mohamed); Harvard T.H. Chan School of Public Health, Boston, Massachusetts, USA (R. Daniels); Broad Institute, Cambridge, Massachusetts, USA (R. Daniels); Australian Defence Force Malaria and Infectious Disease Institute, Brisbane, Queensland, Australia (Q. Cheng); World Health Organization, Geneva, Switzerland (E.A. Kemenang, J. Cunningham)

Main Article

Figure 2

Distributions of HRP2/HRP3 antigen concentrations by pfhrp2 and pfhrp3 genotype for specimens in study of Plasmodium falciparum parasites with pfhrp2 and pfhrp3 deletions, Djibouti, 2019–2020. A) Individual antigen concentrations for all 296 samples successfully genotyped for pfhrp2/3. Dashed line denotes the assay level of quantitation. B) Smoothed kernel density plots for log-transformed HRP2/3 concentration by the four pfhrp2/3 genotypes. HRP2/3, histidine-rich protein 2/3.

Figure 2. Distributions of HRP2/HRP3 antigen concentrations by pfhrp2 and pfhrp3 genotype for specimens in study of Plasmodium falciparum parasites with pfhrp2 and pfhrp3 deletions, Djibouti, 2019–2020. A) Individual antigen concentrations for all 296 samples successfully genotyped for pfhrp2/3. Dashed line denotes the assay level of quantitation. B) Smoothed kernel density plots for log-transformed HRP2/3 concentration by the four pfhrp2/3 genotypes. HRP2/3, histidine-rich protein 2/3.

Main Article

1These authors contributed equally to this article.

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