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Volume 28, Number 2—February 2022
Letter

High Infection Attack Rate after SARS-CoV-2 Delta Surge, Chattogram, Bangladesh

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To the Editor: After an initial serosurvey (1) to understand the prevalence of total antibodies to severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) in residents of the Sitakunda subdistrict was completed, a large epidemic wave hit the area, and nearly all publicly available samples genotyped via GISAID (https://www.gisaid.org) were the SARS-CoV-2 Delta variant (2,3). Of the total confirmed infections during the entire pandemic from the Chattogram District, 48.4% (48,253) were reported June 14–August 31, 2021. During September 21–October 9, 2021, we revisited all enrolled households and collected blood from 84% (1,938/2,307) of those tested in our initial serosurvey (Appendix Figure).

We tested 721 of the initially seronegative participants who agreed to a second blood draw using the same Wantai total Ab receptor-binding domain assay and found that 68% (492/721) had seroconverted in the approximately 3-month period between survey rounds (Appendix Table 1). Participation in the second round was not associated with serostatus in the first round. Among seropositive participants, 87 (18%) had received >1 dose of SARS-CoV-2 vaccine, and 28.3% (140/492) of those who seroconverted reported having had a sudden onset of >1 coronavirus disease–related symptom since the first serosurvey. Assuming no seroreversion between rounds, 88.2% (1,709/1,938) of participants providing blood in both rounds were seropositive by the second serosurvey. Using our previous methods (1), we estimated an adjusted seroprevalence after the Delta wave of 88.2% (95% CrI 85.4%–90.8%) for all participants, 87.9% (95% CrI 85.2%–90.6%) when including only unvaccinated participants (Appendix Table 2). Seroprevalence among children 1–9 years of age remained significantly lower when compared with 25–34 year olds (28% reduced risk for 1–4 and 16% for 5–9 year age groups; p<0.00001), unlike among other age groups (Appendix Table 2). Mirroring evidence from around the world, the Delta variant led to a significant increase in SARS-CoV-2 transmission in Bangladesh, leaving the vast majority of people with detectable serum antibodies.

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Acknowledgments

The authors thank the Ministry of Health and Family Welfare (MOHFW) of Bangladesh. The authors also thank the staff of icddr,b for their dedicated work in the field and laboratory during this pandemic situation. icddr,b is thankful to and supported by the governments of Bangladesh, Canada, Sweden, and the United Kingdom.

This work was supported by the Bill and Melinda Gates Foundation (grant number INV-021879).

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Sonia T. Hegde1, Taufiqur Rahman Bhuiyan1, Marjahan Akhtar, Taufiqul Islam, Juan Dent Hulse, Zahid Hasan Khan, Ishtiakul Islam Khan, Shakeel Ahmed, Mamunur Rashid, Rumana Rashid, Emily S. Gurley, Tahmina Shirin, Ashraful Islam Khan, Andrew S. Azman2Comments to Author , and Firdausi Qadri2
Author affiliations: Johns Hopkins Bloomberg School of Public Health, Baltimore, MD, USA (S.T. Hegde, J.D. Hulse, E.S. Gurley, A.S. Azman); International Centre for Diarrhoeal Disease Research, Bangladesh (T.R. Bhuiyan, M. Akhtar, T. Islam, Z.H. Khan, I.I. Khan, A.I. Khan, F. Qadri); Bangladesh Institute of Tropical and Infectious Diseases, Chattogram, Bangladesh (S. Ahmed, M. Rashid, R. Rashid); Institute of Epidemiology, Disease Control and Research, Dhaka, Bangladesh (T. Shirin); Institute of Global Health, University of Geneva, Geneva, Switzerland (A.S. Azman)

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References

  1. Bhuiyan  TR, Hulse  JD, Hegde  ST, Akhtar  M, Islam  T, Khan  ZH, et al. SARS-CoV-2 seroprevalence before Delta variant surge, Chattogram, Bangladesh, March–June 2021. [cited 2021 Nov 29]. Emerg Infect Dis. 2022;28. .DOIGoogle Scholar
  2. World Health Organization. WHO coronavirus (COVID-19) dashboard: Bangladesh [cited 2021 Nov 21]. https://covid19.who.int/region/searo/country/bd</eref>
  3. GISAID. COVID-19 lineages and variants [cited 2021 Nov 21]. http://www.gisaid.org

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Figure

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Suggested citation for this article: Hegde ST, Bhuiyan TR, Akhtar M, Islam T, Hulse JD, Khan ZH, et al. High infection attack rate after SARS-CoV-2 Delta surge, Sitakunda, Chattogram, Bangladesh. Emerg Infect Dis. 2022 Feb [date cited]. https://dx.doi.org/10.3201/eid2802.212417

DOI: 10.3201/eid2802.212417

Original Publication Date: January 10, 2022

1These first authors contributed equally to this article.

2These senior authors contributed equally to this article.

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Table of Contents – Volume 28, Number 2—February 2022

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Andrew S. Azman, Johns Hopkins Bloomberg School of Public Health, 615 N. Wolfe St, Baltimore, MD 21205, USA

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Page created: January 10, 2022
Page updated: January 10, 2022
Page reviewed: January 10, 2022
The conclusions, findings, and opinions expressed by authors contributing to this journal do not necessarily reflect the official position of the U.S. Department of Health and Human Services, the Public Health Service, the Centers for Disease Control and Prevention, or the authors' affiliated institutions. Use of trade names is for identification only and does not imply endorsement by any of the groups named above.
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