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Volume 28, Number 3—March 2022
Research

Higher Viral Stability and Ethanol Resistance of Avian Influenza A(H5N1) Virus on Human Skin

Risa Bandou, Ryohei HiroseComments to Author , Takaaki Nakaya, Hajime Miyazaki, Naoto Watanabe, Takuma Yoshida, Tomo Daidoji, Yoshito Itoh, and Hiroshi Ikegaya
Author affiliation: Graduate School of Medical Science, Kyoto Prefectural University of Medicine, Kyoto, Japan

Main Article

Figure 3

Effectiveness of disinfectants against various recombinant influenza viruses. A, B) In vitro (A) and ex vivo (B) evaluations were performed, and the residual viral titer after EA exposure is shown. The results are expressed as mean + SD. Dotted horizontal lines represent the detection limit titers. A/crow/Kyoto/53/04 (H5N1) was recombined with the neuraminidase or hemagglutinin gene of A/Duck/Hong Kong/820/80 (H5N3), and the recombinant viruses were designated as rH5N1-H5N3-NA and rH5N1-H5N3-HA. In addition, A/Duck/Hong Kong/820/80 (H5N3) was recombined with the neuraminidase, nonstructural protein, matrix protein, or hemagglutinin gene of A/crow/Kyoto/53/04 (H5N1), and the recombinant viruses were designated as rH5N3-H5N1-NA, rH5N3-H5N1-NS, rH5N3-H5N1-M, or rH5N3-H5N1-HA. log reductions were calculated to evaluate the effectiveness of disinfectants under different conditions (Appendix Table 3). EA, ethyl alcohol.

Figure 3. Effectiveness of disinfectants against various recombinant influenza viruses. A, B) In vitro (A) and ex vivo (B) evaluations were performed, and the residual viral titer after EA exposure is shown. The results are expressed as mean + SD. Dotted horizontal lines represent the detection limit titers. A/crow/Kyoto/53/04 (H5N1) was recombined with the neuraminidase or hemagglutinin gene of A/Duck/Hong Kong/820/80 (H5N3), and the recombinant viruses were designated as rH5N1-H5N3-NA and rH5N1-H5N3-HA. In addition, A/Duck/Hong Kong/820/80 (H5N3) was recombined with the neuraminidase, nonstructural protein, matrix protein, or hemagglutinin gene of A/crow/Kyoto/53/04 (H5N1), and the recombinant viruses were designated as rH5N3-H5N1-NA, rH5N3-H5N1-NS, rH5N3-H5N1-M, or rH5N3-H5N1-HA. log reductions were calculated to evaluate the effectiveness of disinfectants under different conditions (Appendix Table 3). EA, ethyl alcohol.

Main Article

Page created: January 23, 2022
Page updated: February 21, 2022
Page reviewed: February 21, 2022
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