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Volume 28, Number 4—April 2022
CME ACTIVITY - Research

Unique Clinical, Immune, and Genetic Signature in Patients with Borrelial Meningoradiculoneuritis1

Katarina Ogrinc2, Sergio A. Hernández2, Miša Korva, Petra Bogovič, Tereza Rojko, Lara Lusa, Geena Chiumento, Franc Strle3, and Klemen Strle3Comments to Author 
Author affiliations: University Medical Center Ljubljana, Ljubljana, Slovenia (K. Ogrinc, P. Bogovič, T. Rojko, F. Strle); New York State Department of Health, Albany, New York, USA (S.A. Hernández, K. Strle); University of Ljubljana, Ljubljana (M. Korva, L. Lusa); Massachusetts Department of Public Health, Boston, Massachusetts, USA (G. Chiumento)

Main Article

Figure 3

Statistical correlation of the levels of 8 immune mediators in CSF, by clinical manifestation, among patients with LNB treated in Ljubljana, Slovenia, during 2006–2013. A) Mediators associated with innate response are IL-8, IL-10, and CCL3. B) Mediators associated with T-cell adaptive response are CXCL9, CXCL10, and IL-18. C) Mediators associated with B-cell adaptive response are CXCL12 and CXCL13. Black circles represent meningoradiculoneuritis (n = 19); white circles, PFP/meningitis (n = 42); and white squares, suspected LNB (n = 59). Horizontal lines represent median values. Statistical analyses were performed using nonparametric Mann-Whitney rank sum test. p values indicate largest differences for individual patients among groups. CCL, CC motif chemokine ligand; CSF, cerebrospinal fluid; CXCL, CXC motif chemokine ligand; IL, interleukin; LNB, Lyme neuroborreliosis; PFP, peripheral facial palsy.

Figure 3. Statistical correlation of the levels of 8 immune mediators in CSF, by clinical manifestation, among patients with LNB treated in Ljubljana, Slovenia, during 2006–2013. A) Mediators associated with innate response are IL-8, IL-10, and CCL3. B) Mediators associated with T-cell adaptive response are CXCL9, CXCL10, and IL-18. C) Mediators associated with B-cell adaptive response are CXCL12 and CXCL13. Black circles represent meningoradiculoneuritis (n = 19); white circles, PFP/meningitis (n = 42); and white squares, suspected LNB (n = 59). Horizontal lines represent median values. Statistical analyses were performed using nonparametric Mann-Whitney rank sum test. p values indicate largest differences for individual patients among groups. CCL, CC motif chemokine ligand; CSF, cerebrospinal fluid; CXCL, CXC motif chemokine ligand; IL, interleukin; LNB, Lyme neuroborreliosis; PFP, peripheral facial palsy.

Main Article

1Part of the research reported here was presented at the 31st European Congress of Clinical Microbiology & Infectious Diseases (online), July 9–12, 2021.

2These first authors contributed equally to this article.

3These senior authors contributed equally to this article.

Page created: February 22, 2022
Page updated: March 22, 2022
Page reviewed: March 22, 2022
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