Volume 28, Number 5—May 2022
Research
Risk for Asymptomatic Household Transmission of Clostridioides difficile Infection Associated with Recently Hospitalized Family Members
Aaron C. Miller
, Alan T. Arakkal, Daniel K. Sewell, Alberto M. Segre, Sriram V. Pemmaraju, Philip M. Polgreen, and CDC MInD-Healthcare Group
, Alan T. Arakkal, Daniel K. Sewell, Alberto M. Segre, Sriram V. Pemmaraju, Philip M. Polgreen, and CDC MInD-Healthcare Group
Table 4
Results of regression analysis of incidence rate ratio for Clostridioides difficile infection using quasi-Poisson model and 60-day exposure window in study of asymptomatic C. difficile transmission among household members, United States*
| Variable | IRR (95% CI) |
|---|---|
| No. days member was hospitalized within 60 d | |
| 0 | Referent |
| 1–3 | 1.30 (1.19–1.41) |
| 4–10 | 1.46 (1.32–1.62) |
| 11–20 | 1.79 (1.43–2.23) |
| 21–30 | 2.17 (1.48–3.18) |
| >30 |
2.45 (1.66–3.60) |
| Age group, y | |
| 0–17 | Referent |
| 18–40 | 1.71 (1.65–1.78) |
| 41–65 | 2.97 (2.86–3.08) |
| >65 |
9.32 (8.92–9.73) |
| Sex | |
| M | Referent |
| F |
1.30 (1.28–1.33) |
| Outpatient antimicrobial drug use within 60 d | |
| None | Referent |
| Low-risk drugs | 2.69 (2.59–2.79) |
| High-risk drugs |
8.83 (8.63–9.03) |
| PPI use within 30 d |
2.23 (2.15–2.30) |
| Infant <2 y in family | 1.51 (1.44–1.58) |
*Models were adjusted for year, month, and family size. Regression models included an offset for number of enrollment months. Because family hospitalization exposure group was followed for 60 days to identify secondary Clostridioides difficile infection, the length of their enrollment period is 60 days. For the unexposed group, the length of enrollment was the length of a given month. IRR, incident rate ratio; PPI, proton-pump inhibitor.
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