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Volume 28, Number 5—May 2022

Risk for Asymptomatic Household Transmission of Clostridioides difficile Infection Associated with Recently Hospitalized Family Members

Aaron C. MillerComments to Author , Alan T. Arakkal, Daniel K. Sewell, Alberto M. Segre, Sriram V. Pemmaraju, Philip M. Polgreen, and CDC MInD-Healthcare Group
Author affiliation: University of Iowa, Iowa City, Iowa, USA

Main Article

Table 4

Results of regression analysis of incidence rate ratio for Clostridioides difficile infection using quasi-Poisson model and 60-day exposure window in study of asymptomatic C. difficile transmission among household members, United States*

Variable IRR (95% CI)
No. days member was hospitalized within 60 d
0 Referent
1–3 1.30 (1.19–1.41)
4–10 1.46 (1.32–1.62)
11–20 1.79 (1.43–2.23)
21–30 2.17 (1.48–3.18)
2.45 (1.66–3.60)
Age group, y
0–17 Referent
18–40 1.71 (1.65–1.78)
41–65 2.97 (2.86–3.08)
9.32 (8.92–9.73)
M Referent
1.30 (1.28–1.33)
Outpatient antimicrobial drug use within 60 d
None Referent
Low-risk drugs 2.69 (2.59–2.79)
High-risk drugs
8.83 (8.63–9.03)
PPI use within 30 d
2.23 (2.15–2.30)
Infant <2 y in family 1.51 (1.44–1.58)

*Models were adjusted for year, month, and family size. Regression models included an offset for number of enrollment months. Because family hospitalization exposure group was followed for 60 days to identify secondary Clostridioides difficile infection, the length of their enrollment period is 60 days. For the unexposed group, the length of enrollment was the length of a given month. IRR, incident rate ratio; PPI, proton-pump inhibitor.

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Page created: March 08, 2022
Page updated: April 19, 2022
Page reviewed: April 19, 2022
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