Volume 28, Number 5—May 2022
Research
Risk for Asymptomatic Household Transmission of Clostridioides difficile Infection Associated with Recently Hospitalized Family Members
Aaron C. Miller
, Alan T. Arakkal, Daniel K. Sewell, Alberto M. Segre, Sriram V. Pemmaraju, Philip M. Polgreen, and CDC MInD-Healthcare Group
, Alan T. Arakkal, Daniel K. Sewell, Alberto M. Segre, Sriram V. Pemmaraju, Philip M. Polgreen, and CDC MInD-Healthcare Group
Table 2
Bivariate comparisons of unadjusted incidence rates and incidence rate ratios for infection incidence across various patient strata using a 60-day exposure window in study of asymptomatic Clostridioides difficile transmission among household members, United States*
| Variable |
Exposed to previously hospitalized family member <60 days |
Not exposed to previously hospitalized family member <60 days |
Unadjusted IRR |
||||||
| CDI cases |
Total enrollee months |
CDI incidence† |
CDI cases |
Total enrollee months |
CDI incidence† |
||||
| Overall |
3,871 |
69,675,026 |
5.56 |
160,779 |
4,998,101,178 |
3.22 |
1.73 |
||
| Age group, y | |||||||||
| 0–17 | 317 | 24,432,280 | 1.30 | 15,615 | 1,445,786,086 | 1.08 | 1.20 | ||
| 18–40 | 567 | 19,978,891 | 2.84 | 29,718 | 1,427,785,479 | 2.08 | 1.37 | ||
| 41–65 | 1,193 | 19,281,059 | 6.19 | 74,803 | 1,868,106,655 | 4.00 | 1.55 | ||
| >65 |
1,794 |
5,982,798 |
29.99 |
40,643 |
256,422,958 |
15.85 |
1.89 |
||
| Sex | |||||||||
| M | 1,698 | 37,945,564 | 4.47 | 67,378 | 2,488,714,427 | 2.71 | 1.65 | ||
| F |
2,173 |
31,729,463 |
6.85 |
93,401 |
2,509,386,752 |
3.72 |
1.84 |
||
| Outpatient antimicrobial drug use within 60 days | |||||||||
| None | 2,419 | 63,230,032 | 3.83 | 100,792 | 4,575,861,567 | 2.20 | 1.74 | ||
| Low-risk drugs | 292 | 2,979,748 | 9.80 | 11,944 | 201,200,918 | 5.94 | 1.65 | ||
| High-risk drugs |
1,160 |
3,465,248 |
33.48 |
48,043 |
221,038,693 |
21.74 |
1.54 |
||
| PPI use within 30 days | |||||||||
| N | 3,477 | 68,273,806 | 5.09 | 146,185 | 4,913,346,960 | 2.98 | 1.71 | ||
| Y |
394 |
1,401,221 |
28.12 |
14,594 |
84,754,218 |
17.22 |
1.63 |
||
| Infant age <2 y in family | |||||||||
| N | 3,489 | 48,618,765 | 7.18 | 151,291 | 4,597,497,625 | 3.29 | 2.18 | ||
| Y | 382 | 21,056,262 | 1.81 | 9,488 | 400,603,553 | 2.37 | 0.76 |
||
*IRRs compare CDI incidence among persons exposed to a family member previously hospitalized for >1 d relative incidence for to those not exposed to a previously hospitalized family member. The overall incidence rate ratio among those exposed to a previously hospitalized family member relative to those unexposed was 1.73 and was >1 across all strata. CDI, Clostridioides difficile infection; IRR, incidence rate ratio; PPI, proton-pump inhibitor. †Cases per 100,000 enrollee months.
Page created: March 08, 2022
Page updated: April 19, 2022
Page reviewed: April 19, 2022
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