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Volume 28, Number 5—May 2022
Research

Risk for Asymptomatic Household Transmission of Clostridioides difficile Infection Associated with Recently Hospitalized Family Members

Aaron C. MillerComments to Author , Alan T. Arakkal, Daniel K. Sewell, Alberto M. Segre, Sriram V. Pemmaraju, Philip M. Polgreen, and CDC MInD-Healthcare Group
Author affiliation: University of Iowa, Iowa City, Iowa, USA

Main Article

Table 2

Bivariate comparisons of unadjusted incidence rates and incidence rate ratios for infection incidence across various patient strata using a 60-day exposure window in study of asymptomatic Clostridioides difficile transmission among household members, United States*

Variable
Exposed to previously hospitalized family member <60 days
Not exposed to previously hospitalized family member <60 days
Unadjusted IRR
CDI cases
Total enrollee months
CDI incidence†

CDI cases
Total enrollee months
CDI incidence†
Overall
3,871
69,675,026
5.56

160,779
4,998,101,178
3.22
1.73
Age group, y
0–17 317 24,432,280 1.30 15,615 1,445,786,086 1.08 1.20
18–40 567 19,978,891 2.84 29,718 1,427,785,479 2.08 1.37
41–65 1,193 19,281,059 6.19 74,803 1,868,106,655 4.00 1.55
>65
1,794
5,982,798
29.99

40,643
256,422,958
15.85
1.89
Sex
M 1,698 37,945,564 4.47 67,378 2,488,714,427 2.71 1.65
F
2,173
31,729,463
6.85

93,401
2,509,386,752
3.72
1.84
Outpatient antimicrobial drug use within 60 days
None 2,419 63,230,032 3.83 100,792 4,575,861,567 2.20 1.74
Low-risk drugs 292 2,979,748 9.80 11,944 201,200,918 5.94 1.65
High-risk drugs
1,160
3,465,248
33.48

48,043
221,038,693
21.74
1.54
PPI use within 30 days
N 3,477 68,273,806 5.09 146,185 4,913,346,960 2.98 1.71
Y
394
1,401,221
28.12

14,594
84,754,218
17.22
1.63
Infant age <2 y in family
N 3,489 48,618,765 7.18 151,291 4,597,497,625 3.29 2.18
Y 382 21,056,262 1.81 9,488 400,603,553 2.37 0.76

*IRRs compare CDI incidence among persons exposed to a family member previously hospitalized for >1 d relative incidence for to those not exposed to a previously hospitalized family member. The overall incidence rate ratio among those exposed to a previously hospitalized family member relative to those unexposed was 1.73 and was >1 across all strata. CDI, Clostridioides difficile infection; IRR, incidence rate ratio; PPI, proton-pump inhibitor. †Cases per 100,000 enrollee months.

Main Article

Page created: March 08, 2022
Page updated: April 19, 2022
Page reviewed: April 19, 2022
The conclusions, findings, and opinions expressed by authors contributing to this journal do not necessarily reflect the official position of the U.S. Department of Health and Human Services, the Public Health Service, the Centers for Disease Control and Prevention, or the authors' affiliated institutions. Use of trade names is for identification only and does not imply endorsement by any of the groups named above.
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