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Volume 28, Number 6—June 2022
Research

Retrospective Genomic Characterization of a 2017 Dengue Virus Outbreak, Burkina Faso

Andrew G. Letizia1, Catherine B. Pratt1Comments to Author , Michael R. Wiley, Anne T. Fox, Mba Mosore, Bright Agbodzi, Clara Yeboah, Selassie Kumordjie, Nicholas Di Paola, Kone Cisse Assana, David Coulidiaty, Casimir Ouedraogo, Joseph H. Kofi Bonney, William Ampofo, Zékiba Tarnagda, and Lassana SangaréComments to Author 
Author affiliations: Naval Medical Research Unit TWO, Singapore (A.G. Letizia); University of Nebraska Medical Center, Omaha, Nebraska, USA (C.B. Pratt, M.R. Wiley); Naval Medical Research Unit THREE, Ghana Detachment, Accra, Ghana (A.T. Fox); Noguchi Memorial Institute for Medical Research, Accra (M. Mosore, B. Agbodzi, C. Yeboah, S. Kumordjie, J.H.K. Bonney, W. Ampofo); US Army Medical Research Institute of Infectious Disease, Frederick, Maryland, USA (N. Di Paola); Institut de Recherche en Sciences de la Santé, Bobo-Dioulasso, Burkina Faso (K.C. Assana, Z. Tarnagda); Centre Hospitalier Universitaire Yalgado Ouédraogo, Ouagadougou, Burkina Faso (D. Coulidiaty, C. Ouedraogo, L. Sangaré)

Main Article

Figure 7

Amino acid mismatch comparison between 2017 Burkina Faso dengue virus outbreak genomes and virus neutralizing human mAbs for the 3 dengue virus serotypes. The amino acid changes presented are expected to disrupt binding between the envelope protein and heavy chain of the monoclonal antibodies. Dengvaxia vaccine amino acid included for comparison. Asterisk indicates all of the 2017 Burkina Faso dengue virus outbreak genomes share the same amino acid at that position. Numerals represent the E protein amino acid position. CYD, Dengvaxia vaccine; DENV-1, dengue virus serotype 1; DENV-2, dengue virus serotype 2; DENV-3, dengue virus serotype 3; E, envelope; mAb, monoclonal antibody.

Figure 7. Amino acid mismatch comparison between 2017 Burkina Faso dengue virus outbreak genomes and virus neutralizing human mAbs for the 3 dengue virus serotypes. The amino acid changes presented are expected to disrupt binding between the envelope protein and heavy chain of the monoclonal antibodies. Dengvaxia vaccine amino acid included for comparison. Asterisk indicates all of the 2017 Burkina Faso dengue virus outbreak genomes share the same amino acid at that position. Numerals represent the E protein amino acid position. CYD, Dengvaxia vaccine; DENV-1, dengue virus serotype 1; DENV-2, dengue virus serotype 2; DENV-3, dengue virus serotype 3; E, envelope; mAb, monoclonal antibody.

Main Article

1These first authors contributed equally to this article.

Page created: March 18, 2022
Page updated: May 22, 2022
Page reviewed: May 22, 2022
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