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Volume 28, Number 7—July 2022
Research

Outbreak of IncX8 Plasmid–Mediated KPC-3–Producing Enterobacterales Infection, China

Lan Chen1, Wenxiu Ai1, Ying Zhou1, Chunyang Wu, Yinjuan Guo, Xiaocui Wu, Bingjie Wang, Lulin Rao, Yanlei Xu, Jiao Zhang, Liang ChenComments to Author , and Fangyou YuComments to Author 
Author affiliations: Ningbo First Hospital, Ningbo, China (L. Chen); First Affiliated Hospital of Wenzhou Medical University, Wenzhou, China (W. Ai, C. Wu, L. Rao, J. Zhang, F. Yu); Shanghai Pulmonary Hospital, Tongji University School of Medicine, Shanghai, China (Y. Zhou, Y. Guo, X. Wu, B. Wang, Y. Xu, F. Yu); Hackensack Meridian Health Center for Discovery and Innovation, Nutley, New Jersey, USA (L. Chen); Hackensack Meridian School of Medicine, Nutley (L. Chen)

Main Article

Figure 3

Comparative analysis of the blaKPC-3–harboring plasmid pCG2111_KPC3 (GenBank accession no. CP081510), pFK3112_KPC3 (GenBank accession no. CP081509), p15WZ-82-KPC, and Klebsiella pneumoniae p13190 in isolates from an outbreak of KPC 3–producing Enterobacterales infection at a tertiary hospital in Ningbo, Zhejiang Province, China, August 1, 2020–June 30, 2021. Open reading frames are portrayed by arrows and are depicted in different colors on the basis of their predicted gene functions. Red arrows indicate resistance genes, and green arrows indicate genes associated with the type IV secretion system. Orange arrows represent the backbone genes of the plasmid, and yellow arrows denote the mobile elements. Light blue shading denotes shared regions of homology among different plasmids. KPC, K. pneumoniae carbapenemase.

Figure 3. Comparative analysis of the blaKPC-3–harboring plasmid pCG2111_KPC3 (GenBank accession no. CP081510), pFK3112_KPC3 (GenBank accession no. CP081509), p15WZ-82-KPC, and Klebsiella pneumoniae p13190 in isolates from an outbreak of KPC 3–producing Enterobacterales infection at a tertiary hospital in Ningbo, Zhejiang Province, China, August 1, 2020–June 30, 2021. Open reading frames are portrayed by arrows and are depicted in different colors on the basis of their predicted gene functions. Red arrows indicate resistance genes, and green arrows indicate genes associated with the type IV secretion system. Orange arrows represent the backbone genes of the plasmid, and yellow arrows denote the mobile elements. Light blue shading denotes shared regions of homology among different plasmids. KPC, K. pneumoniae carbapenemase.

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1These first authors contributed equally to this article.

Page created: May 05, 2022
Page updated: June 18, 2022
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