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Volume 28, Number 7—July 2022
Research

Measuring Basic Reproduction Number to Assess Effects of Nonpharmaceutical Interventions on Nosocomial SARS-CoV-2 Transmission

George ShirreffComments to Author , Jean-Ralph Zahar, Simon Cauchemez, Laura Temime1, Lulla Opatowski1, and EMEA-MESuRS Working Group on the Nosocomial Modelling of SARS-CoV-22
Author affiliations: Institut Pasteur, Université Paris Cité, Paris, France (G. Shirreff, S. Cauchemez, L. Opatowski); Conservatoire National des Arts et Métiers, Paris (G. Shirreff, L. Temime); University of Versailles Saint-Quentin-en-Yvelines, Montigny-le-Bretonneux, France (G. Shirreff, L. Opatowski); Assistance Publique–Hôpitaux de Paris, Bobigny, France (J.-R. Zahar); PACRI Unit, Paris (L. Temime)

Main Article

Table 2

Characteristics and parameter estimates in hospital wards in a long-term care facility in France used to estimate nosocomial transmission rates of SARS-CoV-2*

Ward No. beds Total no. patients Day of first positive case No. cases β R0† tinit
A2 48 62 11 30 1.29 (0.51–NE) 8.76 (3.47–NE) 2 (−14 to 29)
C0 37 74 16 22 0.56 (0.22–NE) 3.79 (1.50–NE) 4 (−39 to 9)
C2 37 48 7 15 2.13 (0.29–NE) 14.46 (1.97–NE) −8 (−39 to –14)
C3 37 63 24 7 0.42 (0.11–1.30) 2.87 (0.75–8.84) 19 (−9 to 21)

*Estimates and 95% CI for β, R0, and tinit are from the fitting the 1-phase model to data from each ward (Einit = 1). In many instances, the upper bound of the 95% CI for β, and in the most likely value of β for some wards, could not be estimated due to a flat likelihood surface, in which case the value is given as NE. NE, not estimated; β, current transmission rate per day; Einit, number of initial infections at date tinit; R0, basic reproduction number; tinit, date on which the initial infection occurs. †The R0 values were calculated using equation 4 (Appendix).

Main Article

1These authors were co-principal investigators.

2Members of the workgroup are listed at the end of this article.

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Page updated: June 18, 2022
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