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Volume 28, Number 8—August 2022
CME ACTIVITY - Synopsis

Lack of Evidence for Ribavirin Treatment of Lassa Fever in Systematic Review of Published and Unpublished Studies1

Hung-Yuan Cheng, Clare E. French, Alex P. Salam, Sarah Dawson, Alexandra McAleenan, Luke A. McGuinness, Jelena Savović, Peter W. Horby, and Jonathan A.C. SterneComments to Author 
Author affiliations: Population Health Sciences, University of Bristol, Bristol, UK (H.-Y. Cheng, C.E. French, S. Dawson, A. McAleenan, L.A. McGuinness, J. Savović, J.A.C. Sterne); National Institute for Health and Care Research (NIHR) Health Protection Research Unit in Behavioural Science and Evaluation, University of Bristol, Bristol (C.E. French); United Kingdom Public Health Rapid Support Team, London, UK (A.P. Salam); Pandemic Sciences Centre, University of Oxford, Oxford, UK (A.P. Salam, P.W. Horby); NIHR Applied Research Collaboration West, Bristol (J. Savović); International Severe Acute Respiratory and Emerging Infections Consortium, Oxford (P. Horby); NIHR Bristol Biomedical Research Centre, Bristol (J.A.C. Sterne); Health Data Research UK South West, Bristol (J.A.C. Sterne)

Main Article

Figure 2

Summary of risk for bias assessment for a systematic review of published and unpublished studies for evidence for ribavirin treatment of Lassa fever. Bias categories: D1, bias due to confounding; D2, bias in selection of participants into the study; D3, bias in classification of interventions; D4, bias due to deviations from intended interventions; D5, bias due to missing data; D6, bias in measurement of outcomes; D7, bias in selection of the reported result. *IND 16666, unpublished study requested by P.W.H. through the US Freedom of Information Act (Birch & Davis Associates and Sherikon Inc., US Army Medical Research and Development Command, unpub. data, https://media.tghn.org/medialibrary/2019/03/Responsive_Documents_of_Peter_Horby.pdf.pdf; G.V. Ludwig, pers. comm., 2019 March 4, https://media.tghn.org/medialibrary/2019/03/Dr._Ludwig_memo.pdf). †M.-L. Orji et al., unpub. data, https://doi.org/10.20944/preprints202005.0269.v1.

Figure 2. Summary of risk for bias assessment for a systematic review of published and unpublished studies for evidence for ribavirin treatment of Lassa fever. Bias categories: D1, bias due to confounding; D2, bias in selection of participants into the study; D3, bias in classification of interventions; D4, bias due to deviations from intended interventions; D5, bias due to missing data; D6, bias in measurement of outcomes; D7, bias in selection of the reported result. *IND 16666, unpublished study requested by P.W.H. through the US Freedom of Information Act (Birch & Davis Associates and Sherikon Inc., US Army Medical Research and Development Command, unpub. data, https://media.tghn.org/medialibrary/2019/03/Responsive_Documents_of_Peter_Horby.pdf.pdf; G.V. Ludwig, pers. comm., 2019 March 4, https://media.tghn.org/medialibrary/2019/03/Dr._Ludwig_memo.pdf). †M.-L. Orji et al., unpub. data, https://doi.org/10.20944/preprints202005.0269.v1.

Main Article

1Preliminary results from this study were presented at the World Health Organization Emergency Program on December 21, 2019.

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