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Volume 29, Number 1—January 2023
Dispatch

Plasmodium falciparum pfhrp2 and pfhrp3 Gene Deletions in Malaria-Hyperendemic Region, South Sudan

Irene Molina-de la Fuente1, María José Sagrado Benito1Comments to Author , Laurence Flevaud, Janet Ousley, Harriet Akello Pasquale, Ahmed Julla, Abdirashid M. Abdi, Buai Tut Chol, Bakri Abubakr, Agustín BenitoComments to Author , Cristian Casademont, Carolina Nanclares, and Pedro Berzosa
Author affiliations: Institute of Health Carlos III, Madrid, Spain (I. Molina-de la Fuente); Alcala University, Madrid (I.M. de la Fuente, A. Benito, P. Berzosa); Médecins Sans Frontières, Barcelona, Spain (M.J.S. Benito, L. Flevaud, C. Casademont, C. Nanclares); Médecins Sans Frontières, New York, New York, USA (J. Ousley); National Malaria Control Program, Ministry of Health, Juba, South Sudan (H.A. Pasquale, A. Julla); Médecins Sans Frontières, Juba (A.M. Abdi, B.T. Chol); Médecins Sans Frontières, Nairobi, Kenya (B. Abubakr); Centro de Investigación Biomedica en Red de Enfermedades Infecciosas, Madrid (A. Benito, P.J.B. Diaz)

Main Article

Table 1

Frequency of pfhrp2 and pfhrp3 deletion by geographic origin of samples, South Sudan*

Location No isolates included Overall pfhrp2 deletion
 Overall pfhrp3 deletion
No. Frequency, % (95% CI) No. Frequency, % (95% CI)
All sites 518 81 15.64 (12.62–19.06) 104 20.08 (16.71–23.79)
Kasia 50 6 12.00 (4.53–24.31) 11 22.00 (11.53–35.96)
Yambio State Hospital 44 13 29.55 (16.76–45.20) 18 40.91 (26.34–56.75)
Birisi 56 12 21.43 (11.59–34.44) 12 21.43 (11.59–34.44)
Bureangburu 62 7 11.29 (4.66–21.88) 7 11.29 (4.66–21.88)
Bakiwiri 58 6 10.34 (3.89–21.17) 7 12.07 (4.99–23.30)
Gitikiri 60 8 13.33 (5.94–24.59) 14 23.33 (13.38–36.04)
Nambia 70 14 20.00 (11.39–31.27) 12 17.14 (9.18–28.03)
Mamboi 51 5 9.80 (3.26–21.41) 7 13.73 (5.70–26.25)
Masumbu 67 10 14.93 (7.40–25.74) 15 22.39 (13.11–34.22)
p value by χ2 test 0.108 (13.089)
 0.014 (18.988)

*Deletion frequency was calculated by dividing confirmed deletions by all confirmed Plasmodium falciparum samples included for analysis. pfhrp2 and pfhrp3 deletion frequency includes both single and double deletions. All analyses used a 95% CI and a p value of <0.05 for statistical significance.

Main Article

1These authors contributed equally to this article.

Page created: November 17, 2022
Page updated: December 22, 2022
Page reviewed: December 22, 2022
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