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Volume 29, Number 10—October 2023
Dispatch

Pseudomonas aeruginosa High-Risk Sequence Type 463 Co-Producing KPC-2 and AFM-1 Carbapenemases, China, 2020–2022

Piaopiao Zhang1, Wenhao Wu1, Nanfei Wang, Haiting Feng, Jie Wang, Fang Wang, Yan Zhang, Hongchao Chen, Qing Yang, Yan Jiang2, and Tingting Qu2Comments to Author 
Author affiliations: The First Affiliated Hospital of Zhejiang University School of Medicine, Hangzhou, China (P. Zhang, W. Wu, N. Wang, H. Feng, J. Wang, F. Wang, Y. Zhang, H. Chen, Q. Yang, T. Qu); Zhejiang University School of Medicine Sir Run Run Shaw Hospital, Hangzhou (Y. Jiang); Key Laboratory of Microbial Technology and Bioinformatics of Zhejiang Province, Hangzhou (Y. Jiang)

Main Article

Table

Demographics and clinical characteristics of 8 patients infected by Pseudomonas aeruginosa high-risk sequence type 463 co-producing KPC-2 and AFM-1 carbapenemases, China, 2020–2022*

Patient no. Strain Age, y/sex Ward Underlying conditions Sample isolation date Sample type Infection type Therapy† Outcome/Date
1
 ZY94
 90/M
 ICU
 Chronic kidney disease
 2021 Feb 9
 Sputum
 Pulmonary infection
 IMP, PTZ, COL
 Death/2021 Feb 10
2
 ZY156
 77/M
 ED
 Acute toxic encephalopathy
 2021 Feb 25
 Urine
 Urinary tract 
colonization
 SCF
 Discharge/2021 Mar 13
3
 ZY1012
 63/F
 ICU
 Intraabdominal malignancy
 2021 Jul 26
 Ascites
 Intraabdominal infection
 CZA, LEV, COL
 Death/2021 Aug 20
4
 ZY1075
 79/M
 ICU
 Chronic cardiopulmonary disease
 2021 Aug 12
 Urine
 Urinary tract 
colonization
 NA
 Discharge/2021 Aug 13
5
 ZY1167
 71/M
 ICU
 Hematologic malignancy
 2021 Aug 28
 Sputum
 Pulmonary infection
 IMP, PTZ, COL
 Death/2021 Sep 13
6
 ZY1214
 45/M
 Cardiac surgery
 Aortic dissection
 2021 Aug 31
 Urine
 Urinary tract 
colonization
 SCF
 Discharge/2021 Sep 8
7
 ZY36
 61/M
 ICU
 Chronic kidney disease
 2022 Jan 9
 Sputum
 Pulmonary infection
 IMP, SCF, COL
 Death/2022 Jan 17
8 ZY1710 90/F Geriatrics Gallbladder carcinoma 2022 Apr 16 Sputum Pulmonary infection IMP Death/2022 Apr 17

*AFM, Alcaligenes faecalis metallo-β-lactamase; COL, colistin; CZA, ceftazidime/avibactam; ED, emergency department; ICU, intensive care unit; IMP, imipenem; KPC, Klebsiella pneumoniae carbapenemase; LEV, levofloxacin, NA, not applicable (none); PTZ, piperacillin/tazobactam; SCF, cefperazone/sulbactam. †Therapy began after bacterial isolation and identification.

Main Article

1These authors contributed equally to this article.

2These senior authors contributed equally to this article.

Page created: August 08, 2023
Page updated: September 20, 2023
Page reviewed: September 20, 2023
The conclusions, findings, and opinions expressed by authors contributing to this journal do not necessarily reflect the official position of the U.S. Department of Health and Human Services, the Public Health Service, the Centers for Disease Control and Prevention, or the authors' affiliated institutions. Use of trade names is for identification only and does not imply endorsement by any of the groups named above.
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