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Volume 29, Number 10—October 2023
Research

Posttransfusion Sepsis Attributable to Bacterial Contamination in Platelet Collection Set Manufacturing Facility, United States

Ian Kracalik, Alyssa G. Kent, Carlos H. Villa, Paige Gable, Pallavi Annambhotla, Gillian McAllister, Deborah Yokoe, Charles R. Langelier, Kelly Oakeson, Judith Noble-Wang, Orieji Illoh, Alison Laufer Halpin, Anne F. Eder, and Sridhar V. BasavarajuComments to Author 
Author affiliations: Centers for Disease Control and Prevention, Atlanta, Georgia, USA (I. Kracalik, A.G. Kent, P. Gable, P. Annambhotla, G. McAllister, J. Noble-Wang, A.L. Halpin, S.V. Basavaraju); Food and Drug Administration, Silver Spring, Maryland, USA (C.H. Villa, O. Illoh, A.F. Eder); University of California San Francisco School of Medicine, San Francisco, California, USA (D. Yokoe, C.R. Langelier); Utah Department of Health, Salt Lake City, Utah, USA (K. Oakeson)

Main Article

Figure 3

Whole-genome sequencing of Staphylococcus saprophyticus (A) and ACBC (B) isolates implicated in the bacterial contamination of platelet blood products, United States, 2018–2022. Maximum-likelihood phylogenies based on core genes were generated by using Roary (https://github.com/sanger-pathogens/Roary) and RaxML (https://cme.h-its.org); phylogenetic trees were midpoint rooted. Clusters were identified based on SNVPhyl (https://snvphyl.readthedocs.io) and highlighted if they included isolates linked to a sepsis transfusion case. Acinetobacter spp. isolates not falling in the ACBC were also included. Black circles on branches indicate 100% support for the branch of 100 bootstraps. US states are identified by 2-letter postal codes. Scale bars indicate nucleotide substitutions per site. ACBC, Acinetobacter calcoaceticus–baumannii complex; DR, Dominican Republic; PAS, platelet additive solution; PR, Puerto Rico.

Figure 3. Whole-genome sequencing of Staphylococcus saprophyticus (A) and ACBC (B) isolates implicated in the bacterial contamination of platelet blood products, United States, 2018–2022. Maximum-likelihood phylogenies based on core genes were generated by using Roary (https://github.com/sanger-pathogens/Roary) and RaxML (https://cme.h-its.org); phylogenetic trees were midpoint rooted. Clusters were identified based on SNVPhyl (https://snvphyl.readthedocs.io) and highlighted if they included isolates linked to a sepsis transfusion case. Acinetobacter spp. isolates not falling in the ACBC were also included. Black circles on branches indicate 100% support for the branch of 100 bootstraps. US states are identified by 2-letter postal codes. Scale bars indicate nucleotide substitutions per site. ACBC, Acinetobacter calcoaceticus–baumannii complex; DR, Dominican Republic; PAS, platelet additive solution; PR, Puerto Rico.

Main Article

Page created: August 02, 2023
Page updated: September 20, 2023
Page reviewed: September 20, 2023
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