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Volume 29, Number 12—December 2023
Dispatch

Neurotropic Highly Pathogenic Avian Influenza A(H5N1) Virus in Red Foxes, Northern Germany

Christine BaechleinComments to Author , Sven Kleinschmidt, Dorothee Hartmann, Patricia Kammeyer, Anne Wöhlke, Tobias Warmann, Louise Herms, Bianca Kühl, Andreas Beineke, Peter Wohlsein, Timm Harder, and Martin Runge
Author affiliations: Lower Saxony State Office for Consumer Protection and Food Safety, Braunschweig/Hannover, Germany (C. Baechlein, S. Kleinschmidt, D. Hartmann, P. Kammeyer, A. Wöhlke, T. Warmann, L. Herms, M. Runge); University of Veterinary Medicine Hannover Foundation, Hannover, Germany (B. Kühl, A. Beineke, P. Wohlsein); Friedrich-Loeffler-Institut, Greifswald-Insel Riems, Germany (T. Harder)

Main Article

Table

Overview of case history, qRT-PCR results, nucleotide frequency at amino acid position 627 of the PB2 segment, and virus isolation experiments of HPAIV H5N1-positive foxes, Germany*

Animal no. Case history, date of submission Ct values, M segment/H5 segment
 PB2 mutation E627K
 Virus isolation
nt 1879 →G, % nt 1879 →A, %
Brain stem Cerebellum Rhinencephalon
51023-60 Adult, clinical signs, nonspecific, 2023 Jan 13.75/19.49 20.29/25.05 18.07/21.78 99.54 0.46 Positive
51023-61 Found dead, 2023 Jan 28.98/34.60 29.95/36.35 30.45/34.36 ND ND ND
51023-113 Found dead, 2023 Jan 29.16./32.32 31.02/35.55 29.05/32.51 4.53 95.47 ND
51023-124 Adult, clinical signs, CNS, 2023 Feb 23.16/27.61 25.91/30.04 25.40/29.77 99.93 0.07 Positive
51023-261 Pup, clinical signs, CNS, 2023 Mar 16.90/19.17 21.80/23.72 21.01/23.38 99.76 0.23 Positive

*CNS, central nervous system; H, hemagglutinin; HPAIV, highly pathogenic avian influenza virus; M, matrix; ND, not determined; nt, nucleotide; PB2, polymerase basic 2; qRT-PCR, quantitative reverse transcription PCR.

Main Article

Page created: October 03, 2023
Page updated: November 18, 2023
Page reviewed: November 18, 2023
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