Volume 29, Number 12—December 2023
Dispatch
Neurotropic Highly Pathogenic Avian Influenza A(H5N1) Virus in Red Foxes, Northern Germany
Table
Overview of case history, qRT-PCR results, nucleotide frequency at amino acid position 627 of the PB2 segment, and virus isolation experiments of HPAIV H5N1-positive foxes, Germany*
Animal no. | Case history, date of submission | Ct values, M segment/H5 segment |
PB2 mutation E627K |
Virus isolation | |||
---|---|---|---|---|---|---|---|
nt 1879 →G, % | nt 1879 →A, % | ||||||
Brain stem | Cerebellum | Rhinencephalon | |||||
51023-60 | Adult, clinical signs, nonspecific, 2023 Jan | 13.75/19.49 | 20.29/25.05 | 18.07/21.78 | 99.54 | 0.46 | Positive |
51023-61 | Found dead, 2023 Jan | 28.98/34.60 | 29.95/36.35 | 30.45/34.36 | ND | ND | ND |
51023-113 | Found dead, 2023 Jan | 29.16./32.32 | 31.02/35.55 | 29.05/32.51 | 4.53 | 95.47 | ND |
51023-124 | Adult, clinical signs, CNS, 2023 Feb | 23.16/27.61 | 25.91/30.04 | 25.40/29.77 | 99.93 | 0.07 | Positive |
51023-261 | Pup, clinical signs, CNS, 2023 Mar | 16.90/19.17 | 21.80/23.72 | 21.01/23.38 | 99.76 | 0.23 | Positive |
*CNS, central nervous system; H, hemagglutinin; HPAIV, highly pathogenic avian influenza virus; M, matrix; ND, not determined; nt, nucleotide; PB2, polymerase basic 2; qRT-PCR, quantitative reverse transcription PCR.
Page created: October 03, 2023
Page updated: November 18, 2023
Page reviewed: November 18, 2023
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