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Volume 29, Number 2—February 2023
Synopsis

Changing Disease Course of Crimean-Congo Hemorrhagic Fever in Children, Turkey

Pembe Derin Oygar1, Sibel Laçinel Gürlevik, Erdal Sağ, Sare İlbay, Tekin Aksu, Osman Oğuz Demir, Yasemin Coşgun, Selin Aytaç Eyüpoğlu, Jale Karakaya, Şule Ünal Cangül, Ali Bülent Cengiz, and Yasemin ÖzsürekciComments to Author 
Author affiliations: Hacettepe University, Ankara, Turkey (P.D. Oygar, S.L. Gürlevik, E. Sağ, T. Aksu, O.O. Demir, S.A. Eyüpoğlu, J. Karakaya, Ş.Ü. Cangül, A.B. Cengiz, Y. Özsürekci); İhsan Doğramacı Children’s Hospital, Ankara (P.D. Oygar, S.L. Gürlevik, T. Aksu, O.O. Demir, S.A. Eyüpoğlu, Ş.Ü. Cangül, A.B. Cengiz, Y. Özsürekci); Ankara Training and Research Hospital, Ankara (E. Sağ); Hacettepe University Rheumatology Translational Medicine Laboratories, Ankara (S. İlbay); General Directorate of Public Health, Ministry of Health, Microbiology Reference and Biological Materials Laboratory, Ankara (Y. Coşgun)

Main Article

Figure

Quantitative levels of cytokines/chemokines among 12 case-patients with CCHF for 3 time intervals compared with results for controls, Turkey. 1, 1st time interval, 68–72 hours after admission (black); 2, 2nd time interval, 120–132 hours after admission (red); 3, 3rd time interval, 156–180 hours after admission (blue). Controls are shown in green. Time intervals contributing to significant changes designated by number of asterisks (*). *1st time interval; **2nd time interval; ***3rd time interval. CCL, CC chemokine ligand; CXCL, C-X-C motif chemokine ligand; ENA, epithelial neutrophil-activating; HC, healthy controls; IL, interleukin; IFN, interferon; IP, IFN-γ-inducible protein; I-TAC, interferon-inducible T-cell alpha chemoattractant; RANTES, regulated upon activation, normal t cell expressed and presumably secreted; MIP, macrophage inflammatory proteins; NA, not applicable; TARC, hymus- and activation-regulated chemokine.

Figure. Quantitative levels of cytokines/chemokines among 12 case-patients with CCHF for 3 time intervals compared with results for controls, Turkey. 1, 1st time interval, 68–72 hours after admission (black); 2, 2nd time interval, 120–132 hours after admission (red); 3, 3rd time interval, 156–180 hours after admission (blue). Controls are shown in green. Time intervals contributing to significant changes designated by number of asterisks (*). *1st time interval; **2nd time interval; ***3rd time interval. CCL, CC chemokine ligand; CXCL, C-X-C motif chemokine ligand; ENA, epithelial neutrophil-activating; HC, healthy controls; IL, interleukin; IFN, interferon; IP, IFN-γ-inducible protein; I-TAC, interferon-inducible T-cell alpha chemoattractant; RANTES, regulated upon activation, normal t cell expressed and presumably secreted; MIP, macrophage inflammatory proteins; NA, not applicable; TARC, hymus- and activation-regulated chemokine.

Main Article

1Current affiliation: Nicosia State Hospital, Burhan Nalbantoglu General Hospital, Nicosia, Cyprus.

Page created: December 07, 2022
Page updated: January 21, 2023
Page reviewed: January 21, 2023
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