Changing Disease Course of Crimean-Congo Hemorrhagic Fever in Children, Turkey
Pembe Derin Oygar1
, Sibel Laçinel Gürlevik, Erdal Sağ, Sare İlbay, Tekin Aksu, Osman Oğuz Demir, Yasemin Coşgun, Selin Aytaç Eyüpoğlu, Jale Karakaya, Şule Ünal Cangül, Ali Bülent Cengiz, and Yasemin Özsürekci
Author affiliations: Hacettepe University, Ankara, Turkey (P.D. Oygar, S.L. Gürlevik, E. Sağ, T. Aksu, O.O. Demir, S.A. Eyüpoğlu, J. Karakaya, Ş.Ü. Cangül, A.B. Cengiz, Y. Özsürekci); İhsan Doğramacı Children’s Hospital, Ankara (P.D. Oygar, S.L. Gürlevik, T. Aksu, O.O. Demir, S.A. Eyüpoğlu, Ş.Ü. Cangül, A.B. Cengiz, Y. Özsürekci); Ankara Training and Research Hospital, Ankara (E. Sağ); Hacettepe University Rheumatology Translational Medicine Laboratories, Ankara (S. İlbay); General Directorate of Public Health, Ministry of Health, Microbiology Reference and Biological Materials Laboratory, Ankara (Y. Coşgun)
Figure. Quantitative levels of cytokines/chemokines among 12 case-patients with CCHF for 3 time intervals compared with results for controls, Turkey. 1, 1st time interval, 68–72 hours after admission (black); 2, 2nd time interval, 120–132 hours after admission (red); 3, 3rd time interval, 156–180 hours after admission (blue). Controls are shown in green. Time intervals contributing to significant changes designated by number of asterisks (*). *1st time interval; **2nd time interval; ***3rd time interval. CCL, CC chemokine ligand; CXCL, C-X-C motif chemokine ligand; ENA, epithelial neutrophil-activating; HC, healthy controls; IL, interleukin; IFN, interferon; IP, IFN-γ-inducible protein; I-TAC, interferon-inducible T-cell alpha chemoattractant; RANTES, regulated upon activation, normal t cell expressed and presumably secreted; MIP, macrophage inflammatory proteins; NA, not applicable; TARC, hymus- and activation-regulated chemokine.
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