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Volume 29, Number 2—February 2023
Research

Circovirus Hepatitis Infection in Heart-Lung Transplant Patient, France

Philippe Pérot1, Jacques Fourgeaud1, Claire Rouzaud1, Béatrice Regnault, Nicolas Da Rocha, Hélène Fontaine, Jérôme Le Pavec, Samuel Dolidon, Margaux Garzaro, Delphine Chrétien, Guillaume Morcrette, Thierry Jo Molina, Agnès Ferroni, Marianne Leruez-Ville, Olivier Lortholary2, Anne Jamet2, and Marc Eloit2Comments to Author 
Author affiliations: Institut Pasteur Pathogen Discovery Laboratory, Paris, France (P. Pérot, B. Regnault, N. Da Rocha, D. Chrétien, M. Eloit); The OIE Collaborating Center for the Detection and Identification in Humans of Emerging Animal Pathogens, Paris (P. Pérot, B. Regnault, N. Da Rocha, D. Chrétien, M. Eloit); Institut Imagine, Paris (J. Fourgeaud, M. Leruez-Ville); Université Paris Cité, Paris (J. Fourgeaud, A. Jamet); Necker-Enfants Malades Hospital, Paris (J. Fourgeaud, G. Morcrette, T.J. Molina, A. Ferroni, M. Leruez-Ville, A. Jamet); Hôpital Necker Enfants-Malades Centre d'Infectiologie Necker-Pasteur, Paris (C. Rouzaud, M. Garzaro, O. Lortholary); Groupe Hospitalier Paris Saint Joseph-Marie Lannelongue, Équipe Mobile de Microbiologie Clinique, Paris (C. Rouzaud); Hôpital Cochin Département d'Hépatologie-Addictologie, Paris (H. Fontaine); Université Paris–Sud, Paris (J. Le Pavec); Hôpital Marie Lannelongue Service de Pneumologie et Transplantation Pulmonaire, Le Plessis-Robinson, France (J. Le Pavec, S. Dolidon); Institut Necker Enfants Malades, Paris (A. Jamet); Ecole Nationale Vétérinaire d’Alfort, Maisons-Alfort, France (M. Eloit)

Main Article

Figure 1

Clinical and laboratory data over time for a heart-lung transplant patient in France who had cytolytic hepatitis caused by HCirV-1 develop. A–C) Monitoring of patient over time: A) viral loads; B) liver cytolysis markers; C) blood cell counts. D) Patient’s treatment history; red indicates timing of liver biopsy (March 21, 2022). Average values are depicted for HCirV-1 and TTV viral loads in plasma and blood on June 8 and August 3, 2022. *Dose 5mg/day; †solumedrol dose 500 mg/day. ALT, alanine transaminase; AST, aspartate aminotransferase; CMV, cytomegalovirus; EBV, Epstein-Barr virus; GGT, gamma-glutamyl transferase; HCirV-1, human circovirus type 1; IV, intravenous; TTV, Torque teno virus.

Figure 1. Clinical and laboratory data over time for a heart-lung transplant patient in France who had cytolytic hepatitis caused by HCirV-1 develop. A–C) Monitoring of patient over time: A) viral loads; B) liver cytolysis markers; C) blood cell counts. D) Patient’s treatment history; red indicates timing of liver biopsy (March 21, 2022). Average values are depicted for HCirV-1 and TTV viral loads in plasma and blood on June 8 and August 3, 2022. *Dose 5mg/day; †solumedrol dose 500 mg/day. ALT, alanine transaminase; AST, aspartate aminotransferase; CMV, cytomegalovirus; EBV, Epstein-Barr virus; GGT, gamma-glutamyl transferase; HCirV-1, human circovirus type 1; IV, intravenous; TTV, Torque teno virus.

Main Article

1These authors contributed equally to this article.

2These senior authors contributed equally to this article.

Page created: December 06, 2022
Page updated: January 23, 2023
Page reviewed: January 23, 2023
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