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Volume 29, Number 2—February 2023
Research

Circovirus Hepatitis Infection in Heart-Lung Transplant Patient, France

Philippe Pérot1, Jacques Fourgeaud1, Claire Rouzaud1, Béatrice Regnault, Nicolas Da Rocha, Hélène Fontaine, Jérôme Le Pavec, Samuel Dolidon, Margaux Garzaro, Delphine Chrétien, Guillaume Morcrette, Thierry Jo Molina, Agnès Ferroni, Marianne Leruez-Ville, Olivier Lortholary2, Anne Jamet2, and Marc Eloit2Comments to Author 
Author affiliations: Institut Pasteur Pathogen Discovery Laboratory, Paris, France (P. Pérot, B. Regnault, N. Da Rocha, D. Chrétien, M. Eloit); The OIE Collaborating Center for the Detection and Identification in Humans of Emerging Animal Pathogens, Paris (P. Pérot, B. Regnault, N. Da Rocha, D. Chrétien, M. Eloit); Institut Imagine, Paris (J. Fourgeaud, M. Leruez-Ville); Université Paris Cité, Paris (J. Fourgeaud, A. Jamet); Necker-Enfants Malades Hospital, Paris (J. Fourgeaud, G. Morcrette, T.J. Molina, A. Ferroni, M. Leruez-Ville, A. Jamet); Hôpital Necker Enfants-Malades Centre d'Infectiologie Necker-Pasteur, Paris (C. Rouzaud, M. Garzaro, O. Lortholary); Groupe Hospitalier Paris Saint Joseph-Marie Lannelongue, Équipe Mobile de Microbiologie Clinique, Paris (C. Rouzaud); Hôpital Cochin Département d'Hépatologie-Addictologie, Paris (H. Fontaine); Université Paris–Sud, Paris (J. Le Pavec); Hôpital Marie Lannelongue Service de Pneumologie et Transplantation Pulmonaire, Le Plessis-Robinson, France (J. Le Pavec, S. Dolidon); Institut Necker Enfants Malades, Paris (A. Jamet); Ecole Nationale Vétérinaire d’Alfort, Maisons-Alfort, France (M. Eloit)

Main Article

Table

Samples tested by qPCR to detect and quantify human circovirus type 1 infection in a heart-lung transplant patient in France*

Sample type Sampling date Ct values Virus copies†
Serum 2017 Oct 11 Negative Negative
Serum 2019 Aug 28 Negative Negative
Serum 2020 Jun 12 Negative Negative
Serum 2020 Jul 24 Negative Negative
Plasma 2020 Sep 17 17.9 3.24 × 107
Serum 2020 Sep 23 32.4 2.00 × 103
Serum 2021 Nov 05 12.4 1.25 × 109
Serum 2021 Nov 18 13.9 4.38 × 108
Feces 2021 Nov 19 23.5 3.12 × 105
Serum 2021 Nov 30 15.1 2.07 × 108
Serum 2021 Dec 10 17.4 4.49 × 107
Serum 2022 Jan 05 16.3 9.19 × 107
BAL 2022 Jan 06 24.8 3.24 × 105
Serum 2022 Jan 12 8.4 1.72 × 1010
Serum 2022 Jan 25 11.5 2.19 × 109
Feces 2022 Jan 27 25.5 7.98 × 104
Plasma 2022 Mar 10 15.3 1.77 × 108
Serum 2022 Mar 14 14.6 2.77 × 108
Plasma 2022 Mar 16 15.1 2.08 × 108
Serum 2022 Mar 18 14.3 3.52 × 108
Liver biopsy 2022 Mar 21 16.4 3.57 × 108
Feces 2022 Apr 01 23.7 2.68 × 105
Blood 2022 Apr 04 10.0 5.81 × 109
Serum 2022 May 05 18.1 2.73 × 107
Serum 2022 May 05 17.2 4.92 × 107
Feces 2022 May 11 28.6 1.06 × 104
Urine 2022 Jun 08 26.4 1.13 × 105
Saliva 2022 Jun 08 26.0 1.45 × 105
Plasma 2022 Jun 08 19.2 1.36 × 107
Blood 2022 Jun 08 20.3 6.36 × 106
Feces 2022 Jun 09 27.2 2.60 × 104
Blood 2022 Aug 03 18.8 1.70 × 107
Plasma 2022 Aug 03 17.5 4.01 × 107

*Virus copies are per gram for liver biopsy and feces samples, per milliliter for all other samples. BAL, bronchoalveolar lavage; qPCR, quantitative PCR; Ct, cycle threshold.

Main Article

1These authors contributed equally to this article.

2These senior authors contributed equally to this article.

Page created: December 06, 2022
Page updated: January 23, 2023
Page reviewed: January 23, 2023
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