Skip directly to site content Skip directly to page options Skip directly to A-Z link Skip directly to A-Z link Skip directly to A-Z link
Volume 29, Number 4—April 2023
Research Letter

Experimental Infection of North American Deer Mice with Clade I and II Monkeypox Virus Isolates

Yvon Deschambault, Levi Klassen, Geoff Soule, Kevin Tierney, Kimberly Azaransky, Angela Sloan, and David SafronetzComments to Author 
Author affiliations: Public Health Agency of Canada, Winnipeg, Manitoba, Canada (Y. Deschambault, L. Klassen, G. Soule, K. Tierney, K. Azaransky, A. Sloan, D. Safronetz); Canadian Mennonite University, Winnipeg (L. Klassen); University of Manitoba, Winnipeg (D. Safronetz)

Main Article

Figure

Monkeypox virus infectious titers from lung and nasal turbinate samples from experimentally infected deer mice. Groups of 12 deer mice (6 male, 6 female) were experimentally infected with monkeypox virus isolates SP2833, USA-2003 (both clade II), or V79-1-005 (clade II) through the intranasal route. Lung and nasal turbinates were collected from 3 male and 3 female rodents at days 4 and 10 postinfection and infectious titers assessed using standard tissue culture methods. Shown are the infectious titers for individual specimens (dots) or median values (solid lines) and interquartile ranges (error bars) for nasal turbinate specimens collected at day 4 (A) and day 10 (B) postinfection and lung specimens collected at day 4 (C) and day 10 (D) postinfection. Dotted line represents the lower limit of detection of the assay. TCID50, median tissue culture infectious dose.

Figure. Monkeypox virus infectious titers from lung and nasal turbinate samples from experimentally infected deer mice. Groups of 12 deer mice (6 male, 6 female) were experimentally infected with monkeypox virus isolates SP2833, USA-2003 (both clade II), or V79-1-005 (clade II) through the intranasal route. Lung and nasal turbinates were collected from 3 male and 3 female rodents at days 4 and 10 postinfection and infectious titers assessed using standard tissue culture methods. Shown are the infectious titers for individual specimens (dots) or median values (solid lines) and interquartile ranges (error bars) for nasal turbinate specimens collected at day 4 (A) and day 10 (B) postinfection and lung specimens collected at day 4 (C) and day 10 (D) postinfection. Dotted line represents the lower limit of detection of the assay. TCID50, median tissue culture infectious dose.

Main Article

Page created: February 02, 2023
Page updated: March 21, 2023
Page reviewed: March 21, 2023
The conclusions, findings, and opinions expressed by authors contributing to this journal do not necessarily reflect the official position of the U.S. Department of Health and Human Services, the Public Health Service, the Centers for Disease Control and Prevention, or the authors' affiliated institutions. Use of trade names is for identification only and does not imply endorsement by any of the groups named above.
file_external