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Experimental Infection of North American Deer Mice with Clade I and II Monkeypox Virus Isolates

Yvon Deschambault, Levi Klassen, Geoff Soule, Kevin Tierney, Kimberly Azaransky, Angela Sloan, and David Safronetz

Author affiliations: Public Health Agency of Canada, Winnipeg, Manitoba, Canada (Y. Deschambault, L. Klassen, G. Soule, K. Tierney, K. Azaransky, A. Sloan, D. Safronetz); Canadian Mennonite University, Winnipeg (L. Klassen); University of Manitoba, Winnipeg (D. Safronetz)

Main Article

Summary of PCR results of selected organs collected from deer mice experimentally infected with 3 different MPXV isolates*

Tissue	Sex	MPXV/SP2833		USA-2003		MPXV/V79-1-005
Tissue	Sex	4 dpi	10 dpi	4 dpi	10 dpi	4 dpi	10 dpi
Nasal turbinate	M	3/3 (100)	1/3 (33)	3/3 (100)	3/3 (100)	2/3 (67)	2/3 (67)
	F	3/3 (100)	3/3 (100)	3/3 (100)	2/3 (67)	3/3 (100)	2/3 (67)
	Total	6/6 (100)	4/6 (67)	6/6 (100)	5/6 (83)	5/6 (83)	4/6 (67)
Lung	M	3/3 (100)	0/3 (0)	3/3 (100)	3/3 (100)	3/3 (100)	2/3 (67)
	F	3/3 (100)	1/3 (33)	3/3 (100)	1/3 (33)	3/3 (100)	2/3 (67)
	Total	6/6 (100)	1/6 (17)	6/6 (100)	4/6 (67)	6/6 (100)	4/6 (67)
Heart	M	1/3 (33)	0/3 (0)	2/3 (67)	0/3 (0)	1/3 (33)	0/3 (0)
	F	0/3 (0)	0/3 (0)	0/3 (0)	0/3 (0)	0/3 (0)	0/3 (0)
	Total	1/6 (17)	0/6 (0)	2/6 (33)	0/6 (0)	1/6 (17)	0/6 (0)
Liver	M	0/3 (0)	0/3 (0)	3/3 (100)	0/3 (0)	2/3 (67)	0/3 (0)
	F	0/3 (0)	0/3 (0)	3/3 (100)	2/3 (67)	3/3 (100)	0/3 (0)
	Total	0/6 (0)	0/6 (0)	6/6 (100)	2/6 (33)	5/6 (83)	0/6 (0)
Spleen	M	1/3 (33)	0/3 (0)	3/3 (100)	1/3 (33)	2/3 (67)	0/3 (0)
	F	0/3 (0)	0/3 (0)	3/3 (100)	1/3 (33)	3/3 (100)	0/3 (0)
	Total	1/6 (17)	0/6 (0)	6/6 (100)	2/6 (33)	5/6 (83)	0/6 (0)
Small intestine	M	1/3 (33)	0/3 (0)	1/3 (33)	0/3 (0)	0/3 (0)	0/3 (0)
	F	0/3 (0)	0/3 (0)	2/3 (67)	0/3 (0)	0/3 (0)	0/3 (0)
	Total	1/6 (17)	0/6 (0)	3/6 (50)	0/6 (0)	0/6 (0)	0/6 (0)
Oral swab	M	3/3 (100)	1/3 (33)	3/3 (100)	1/3 (33)	1/3 (33)	0/3 (0)
	F	2/3 (67)	1/3 (33)	3/3 (100)	2/3 (67)	1/3 (33)	0/3 (0)
	Total	5/6 (83)	2/6 (33)	6/6 (100)	3/6 (50)	2/6 (33)	0/6 (0)
Rectal swab	M	3/3 (100)	1/3 (33)	3/3 (100)	2/3 (67)	0/3 (0)	1/3 (33)
	F	2/3 (67)	1/3 (33)	1/3 (33)	2/3 (67)	0/3 (0)	0/3 (0)
	Total	5/6 (83)	2/6 (33)	4/6 (67)	4/6 (67)	0/6 (0)	1/6 (17)

*Values are no. (%). dpi, days postinfection; MPXV, monkeypox virus.

Main Article

Page created: February 02, 2023

Page updated: March 21, 2023

Page reviewed: March 21, 2023

The conclusions, findings, and opinions expressed by authors contributing to this journal do not necessarily reflect the official position of the U.S. Department of Health and Human Services, the Public Health Service, the Centers for Disease Control and Prevention, or the authors' affiliated institutions. Use of trade names is for identification only and does not imply endorsement by any of the groups named above.

Volume 29, Number 4—April 2023

Research Letter

Experimental Infection of North American Deer Mice with Clade I and II Monkeypox Virus Isolates

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