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Volume 29, Number 6—June 2023
Synopsis

Association of Persistent Symptoms after Lyme Neuroborreliosis and Increased Levels of Interferon-α in Blood

Sergio A. Hernández, Katarina Ogrinc, Miša Korva, Andrej Kastrin, Petra Bogovič, Tereza Rojko, Keith W. Kelley, Janis J. Weis, Franc Strle, and Klemen StrleComments to Author 
Author affiliations: Tufts University School of Medicine, Boston, Massachusetts, USA (S.A. Hernández, K. Strle); New York State Department of Health, Albany, New York, USA (S.A. Hernández, K. Strle); University Medical Center Ljubljana, Ljubljana, Slovenia (K. Ogrinc, P. Bogovič, T. Rojko, F. Strle}; University of Ljubljana, Ljubljana (M. Korva, A. Kastrin); University of Illinois, Urbana-Champaign, Illinois, USA (K.W. Kelley); University of Utah, Salt Lake City, Utah, USA (J.J. Weis)

Main Article

Figure 4

Serum IFN-α levels of individual patients with Lyme neuroborreliosis in Slovenia at each follow-up timepoint according to PTLDS severity in study of association of persistent symptoms after Lyme neuroborreliosis and increased levels of interferon-α in blood. A) T = 0; B) T = 2 wks; C) T = 3 mo; D) T = 6 mo; E) T = 12 mo. Levels of interferon-α in serum for individual patients throughout the 1-year follow-up are shown. Solid black lines symbolize median values, and shaded area between dotted lines indicates interquartile range. Statistical analyses were performed by using nonparametric Mann-Whitney rank-sum tests. Significant p values for each comparison are shown above the corresponding brackets. IFN, interferon; PTLDS, posttreatment Lyme disease symptoms or syndrome.

Figure 4. Serum IFN-α levels of individual patients with Lyme neuroborreliosis in Slovenia at each follow-up timepoint according to PTLDS severity in study of association of persistent symptoms after Lyme neuroborreliosis and increased levels of interferon-α in blood. A) T = 0; B) T = 2 wks; C) T = 3 mo; D) T = 6 mo; E) T = 12 mo. Levels of interferon-α in serum for individual patients throughout the 1-year follow-up are shown. Solid black lines symbolize median values, and shaded area between dotted lines indicates interquartile range. Statistical analyses were performed by using nonparametric Mann-Whitney rank-sum tests. Significant p values for each comparison are shown above the corresponding brackets. IFN, interferon; PTLDS, posttreatment Lyme disease symptoms or syndrome.

Main Article

Page created: March 23, 2023
Page updated: May 17, 2023
Page reviewed: May 17, 2023
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