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Volume 29, Number 7—July 2023
Research

Effect of Norovirus Inoculum Dose on Virus Kinetics, Shedding, and Symptoms

Yang GeComments to Author , W. Zane Billings, Antone Opekun, Mary Estes, David Graham, Juan Leon, Katia Koelle, Ye Shen, Robert Atmar, Benjamin Lopman, and Andreas HandelComments to Author 
Author affiliations: University of Southern Mississippi School of Health Professions, Hattiesburg, Mississippi, USA (Y. Ge); University of Georgia, Athens, Georgia, USA (W.Z. Billings, Y. Shen, A. Handel); Baylor College of Medicine, Houston, Texas, USA (A. Opekun, M. Estes, D. Graham, R. Atmar); Emory University, Atlanta, Georgia, USA (J. Leon, K. Koelle, B. Lopman)

Main Article

Figure 1

Total virus shedding in feces and vomit of patients challenged with norovirus in study of the effect of norovirus inoculum dose on virus kinetics, shedding, and symptoms. A) Cumulative virus shedding in feces. B) Cumulative virus shedding in vomit. Open circles represent raw data points. Lines and shaded regions indicate means and 95% CrIs of the fitted Bayesian model. Missing values attributable to limits of detection were replaced with fixed values (Appendix). CrI, credible interval; GEC, genomic equivalent copies; RT-PCR, reverse transcription PCR.

Figure 1. Total virus shedding in feces and vomit of patients challenged with norovirus in study of the effect of norovirus inoculum dose on virus kinetics, shedding, and symptoms. A) Cumulative virus shedding in feces. B) Cumulative virus shedding in vomit. Open circles represent raw data points. Lines and shaded regions indicate means and 95% CrIs of the fitted Bayesian model. Missing values attributable to limits of detection were replaced with fixed values (Appendix). CrI, credible interval; GEC, genomic equivalent copies; RT-PCR, reverse transcription PCR.

Main Article

Page created: May 09, 2023
Page updated: June 20, 2023
Page reviewed: June 20, 2023
The conclusions, findings, and opinions expressed by authors contributing to this journal do not necessarily reflect the official position of the U.S. Department of Health and Human Services, the Public Health Service, the Centers for Disease Control and Prevention, or the authors' affiliated institutions. Use of trade names is for identification only and does not imply endorsement by any of the groups named above.
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