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Volume 29, Number 7—July 2023
Research

Effect of Norovirus Inoculum Dose on Virus Kinetics, Shedding, and Symptoms

Yang GeComments to Author , W. Zane Billings, Antone Opekun, Mary Estes, David Graham, Juan Leon, Katia Koelle, Ye Shen, Robert Atmar, Benjamin Lopman, and Andreas HandelComments to Author 
Author affiliations: University of Southern Mississippi School of Health Professions, Hattiesburg, Mississippi, USA (Y. Ge); University of Georgia, Athens, Georgia, USA (W.Z. Billings, Y. Shen, A. Handel); Baylor College of Medicine, Houston, Texas, USA (A. Opekun, M. Estes, D. Graham, R. Atmar); Emory University, Atlanta, Georgia, USA (J. Leon, K. Koelle, B. Lopman)

Main Article

Figure 3

Associations between 4 characteristics of fecal viral shedding kinetics and levels of inoculum dose in patients in study of the effect of norovirus inoculum dose on virus kinetics, shedding, and symptoms. A) Shedding onset (time at which virus load reaches limit of detection 1). B) Time to virus peak shedding. C) Shedding duration (amount of time where virus load was above limit of detection 1). D) Total virus load (area under the fitted trajectory). Lines and shaded regions indicate means and 95% credible intervals of the posterior samples of the fitted time series model. RT-PCR, reverse transcription PCR.

Figure 3. Associations between 4 characteristics of fecal viral shedding kinetics and levels of inoculum dose in patients in study of the effect of norovirus inoculum dose on virus kinetics, shedding, and symptoms. A) Shedding onset (time at which virus load reaches limit of detection 1). B) Time to virus peak shedding. C) Shedding duration (amount of time where virus load was above limit of detection 1). D) Total virus load (area under the fitted trajectory). Lines and shaded regions indicate means and 95% credible intervals of the posterior samples of the fitted time series model. RT-PCR, reverse transcription PCR.

Main Article

Page created: May 09, 2023
Page updated: June 20, 2023
Page reviewed: June 20, 2023
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