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Volume 29, Number 7—July 2023
Research

Effect of Norovirus Inoculum Dose on Virus Kinetics, Shedding, and Symptoms

Yang GeComments to Author , W. Zane Billings, Antone Opekun, Mary Estes, David Graham, Juan Leon, Katia Koelle, Ye Shen, Robert Atmar, Benjamin Lopman, and Andreas HandelComments to Author 
Author affiliations: University of Southern Mississippi School of Health Professions, Hattiesburg, Mississippi, USA (Y. Ge); University of Georgia, Athens, Georgia, USA (W.Z. Billings, Y. Shen, A. Handel); Baylor College of Medicine, Houston, Texas, USA (A. Opekun, M. Estes, D. Graham, R. Atmar); Emory University, Atlanta, Georgia, USA (J. Leon, K. Koelle, B. Lopman)

Main Article

Figure 2

Fitted virus concentration (GEC/g) in feces of patients challenged with norovirus in study of the effect of norovirus inoculum dose on virus kinetics, shedding, and symptoms. A) Fitted curves showing the full infection time-course. Onset is time at which virus load rose to the LOD1 level. Duration is amount of time where virus load was above the LOD1 level. Peak is time to virus peak shedding. B) Zoomed in plot of the first 7 days to better show the initial increase and peak. Curves and shaded regions indicate means and credible intervals of the fitted time series Bayesian model. LOD1 and LOD2 lines indicate the 2 different limits of detection. Missing values attributable to limits of detection were treated as censors (Appendix). AUC, area under virus concentration curve; GEC, genomic equivalent copies; LOD, limit of detection; RT-PCR, reverse transcription PCR.

Figure 2. Fitted virus concentration (GEC/g) in feces of patients challenged with norovirus in study of the effect of norovirus inoculum dose on virus kinetics, shedding, and symptoms. A) Fitted curves showing the full infection time-course. Onset is time at which virus load rose to the LOD1 level. Duration is amount of time where virus load was above the LOD1 level. Peak is time to virus peak shedding. B) Zoomed in plot of the first 7 days to better show the initial increase and peak. Curves and shaded regions indicate means and credible intervals of the fitted time series Bayesian model. LOD1 and LOD2 lines indicate the 2 different limits of detection. Missing values attributable to limits of detection were treated as censors (Appendix). AUC, area under virus concentration curve; GEC, genomic equivalent copies; LOD, limit of detection; RT-PCR, reverse transcription PCR.

Main Article

Page created: May 09, 2023
Page updated: June 20, 2023
Page reviewed: June 20, 2023
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