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Volume 29, Number 7—July 2023
Research

Triplex ELISA for Assessing Durability of Taenia solium Seropositivity after Neurocysticercosis Cure

Nina L. Tang, Theodore E. Nash, Madelynn Corda, Thomas B. Nutman, and Elise M. O’ConnellComments to Author 
Author affiliation: National Institutes of Health, Bethesda, Maryland, USA

Main Article

Figure 1

Sensitivity and specificity of a triplex assay to determine durability of Taenia solium seropositivity after neurocysticercosis cure. The assay combines 3 families of T. solium antigens: A) T24H; B) GP50; and C) Ts18var3. Receiver operating characteristic curves were produced by testing serum from 52 persons who were T. solium–negative and 100 neurocysticercosis patients with positive enzyme-linked immunoelectrotransfer blot results: 17 with parenchymal disease, 16 with ventricular disease, 35 with subarachnoid disease, and 32 putative positives (patients with detectable levels of circulating T. solium antigen, T. solium DNA, or both).

Figure 1. Sensitivity and specificity of a triplex assay to determine durability of Taenia solium seropositivity after neurocysticercosis cure. The assay combines 3 families of T. solium antigens: A) T24H; B) GP50; and C) Ts18var3. Receiver operating characteristic curves were produced by testing serum from 52 persons who were T. solium–negative and 100 neurocysticercosis patients with positive enzyme-linked immunoelectrotransfer blot results: 17 with parenchymal disease, 16 with ventricular disease, 35 with subarachnoid disease, and 32 putative positives (patients with detectable levels of circulating T. solium antigen, T. solium DNA, or both).

Main Article

Page created: May 08, 2023
Page updated: June 20, 2023
Page reviewed: June 20, 2023
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