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Volume 30, Number 10—October 2024
Research
Virulence of Burkholderia pseudomallei ATS2021 Unintentionally Imported to United States in Aromatherapy Spray
Table
Median lethal dose of aerosolized Burkholderia mallei ATS2021 in C57BL/6 and BALB/c mice*
Mice† | Day | Inhaled dose | LD50 (95% CI) | TTD median (95% CI) | TTD mean (SE) |
---|---|---|---|---|---|
C57BL/6 |
21 | 9.90 × 10–1 | 56.4 CFU (21.3–150.2) | >21 | >21 |
1.32 ×101 | >21 | 16.5 (0.7) | |||
1.07 ×102 | 18.0 (11.0–UD) | 15.9 (0.9) | |||
1.15 ×103 | 4.0 (3.0–5.0) | 4.4 (0.3) | |||
4.49 ×103 | 3.0 (UD) | 3.1 (0.1) | |||
60 |
9.9 × 10–1 | 5.8 CFU (2.0–15.1) |
>60 | 51.0 (.) | |
1.32 ×101 | 41.5 (12.0–UD) | 39.3 (5.6) | |||
1.07 ×102 | 18.0 (11.0–26.0) | 20.9 (3.2) | |||
1.15 ×103 | 4.0 (3.0–5.0) | 4.4 (0.3) | |||
4.49 ×103 |
3.0 (UD) |
3.1 (0.1) |
|||
BALB/c | 21 | 4.00 × 10–1 | 4.1 CFU (1.8–11.3) | >21 | 4.0 (.) |
2 | >21 | 4.9 (0.1) | |||
2.05 ×101 | 4.0 (3.0 –4.0) | 4.3 (0.3) | |||
1.86 ×102 | 3.0 (UD) | 3.1 (0.1) | |||
9.60 ×102 | 3.0 (2.0–3.0) | 2.9 (0.1) | |||
60 | 4.00 × 10–1 | 4.1 CFU (1.8–11.3) | >60 | 4.0 (.) | |
2 | >60 | 4.9 (0.1) | |||
2.05 ×101 | 4.0 (3.0–4.0) | 4.3 (0.3) | |||
1.86E ×102 | 3.0 (UD) | 3.1 (0.1) | |||
9.60 ×102 | 3.0 (2.0–3.0) | 2.9 (0.1) |
*LD50, 50% lethal dose; TTD, time to death or euthanasia in accordance with early intervention criter†ia; UD, undetermined. †Female; 7–9 weeks of age at time of exposure to aerosolized bacteria.
Page created: September 11, 2024
Page updated: September 11, 2024
Page reviewed: September 11, 2024
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