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Volume 30, Number 11—November 2024
Research

Detection in Orchards of Predominant Azole-Resistant Candida tropicalis Genotype Causing Human Candidemia, Taiwan

Kuo-Yun Tseng1, Yin-Zhi Chen1, Zi-Li Zhou, Jyh-Nong Tsai, Min-Nan Tseng, Hsing-Lung Liu, Chi-Jung Wu, Yu-Chieh Liao, Chih-Chao Lin, De-Jiun Tsai, Feng-Jui Chen, Li-Yun Hsieh, Kuan-Chung Huang, Chun-Hua Huang, Kai-Ting Chen, Wen-Li Chu, Chiao-Mei Lin, Shu-Man Shih, Chao Agnes Hsiung, Yee-Chun Chen, Huey-Kang Sytwu, Yun-Liang Yang, and Hsiu-Jung LoComments to Author 
Author affiliation: National Tsing Hua University, Hsinchu, Taiwan (K.-Y. Tseng); National Health Research Institutes, Miaoli, Taiwan (K.-Y. Tseng, Y.-Z. Chen, Z.-L. Zhou, C.-J. Wu, Y.-C. Liao, C.-C. Lin, D.-J. Tsai, F.-J. Chen, L.-Y. Hsieh, K.-C. Huang, C.-H. Huang, K.-T. Chen, W.-L. Chu, C.-M. Lin, S.-M. Shih, C.A. Hsiung, Y.-C. Chen, H.-K. Sytwu, H.-J. Lo); National Yang Ming Chiao Tung University, Hsinchu (Z.-L. Zhou, Y.-L. Yang, H.-J. Lo); Taiwan Agricultural Research Institute, Taichung, Taiwan (J.-N. Tsai); Kaohsiung District Agricultural Research and Extension Station, Pingtung, Taiwan (M.-N. Tseng); Taichung District Agricultural Research and Extension Station, CHangHua, Taiwan (H.-L. Liu); National Cheng Kung University Hospital and Medical College, Tainan, Taiwan (C.-J. Wu); National Taiwan University Hospital College of Medicine, Taipei, Taiwan (Y.-C. Chen); China Medical University, Taichung (H.-J. Lo)

Main Article

Table 3

Characteristics of Candida tropicalis isolates from agricultural and clinical settings in study of detection in orchards of predominant azole-resistant C. tropicalis genotype causing human candidemia, Taiwan*

Strain Source Clade DST Fluconazole
 Erg11†
 Upc2†
 mRNA level‡
 MLST ID§
S/R MIC, mg/L Y132F/S154F L168P/A251T/Q287S ERG11 CDR1 MDR1
ATCC750 Patient N914¶ 914 S 2 YS/YS LTS/LTS ND ND ND 1829
YM140066 Ascites 4 506 R 64 YS/FF (9) LAQ/PTS 5.44 0.64 0.36 831
YM140132 Urine 4 506 R 32 YS/FF (4) LAQ/LTS 3.08 0.56 0.31 1765
YM140298 Urine 3 585 R 8 YS/YS LAQ/LAQ 0.67 0 0.26 825
YM140372 Sputum 4 225 R 32 YS/FF (6) LAQ/LAQ 4.59 0.41 0.24 1762
YM140441 Urine 4 506 R 32 YS/FF (5) LAQ/PTS 4.88 0.48 0.22 1766
YM140586 Blood 4 225 R 64 YS/FF (9) LAQ/LTS 4.56 0.57 0.07 833
YM141055 Sputum 2 153 R >64 YS/YS LAQ/LAQ 1.24 0.71 1.3 1753
YFA120301 Soil 4 225 R 32 YS/FF (6) LAQ/PTS 9.59 0.61 2.43 1756
YFA120472 Fruit 8 169 R 16 YS/YS LAQ/LAQ 1.08 4.24 0.62 1754
YFA120760 Fruit 4 225 R 64 YS/FF (9) LAQ/PTS 12.98 0.78 2.96 1757
YFA121702 Soil 4 506 R 32 YS/FF (6) LAQ/PTS 5.81 0.83 2.38 1763
YFA121900-2 Fruit 4 225 R 64 YS/FF (4) LAQ/PTS ND ND ND 1759
YFA122361 Soil 4 506 R 32 YS/FF (5) LAQ/LTS 3.81 0.61 0.54 1764
YFA123343-1 Fruit 4 225 R 32 YS/FF (8) LAQ/PTS 10.85 0.92 0.53 1760
YFA123757 Soil 4 225 R 64 YS/FF (8) LAQ/PTS 11.28 0.77 1.11 1761
YM140156 Blood 7 139 S 0.25 YS/YS LAQ/LAQ ND ND ND 1748
YM140225 Blood 5 140 S 0.25 YS/YS LTS/LTS ND ND ND 1750
YM140458 Sputum 11 923 S 0.25 YS/YS LAQ/LAS ND ND ND 1767
YM140470 Urine 6 149 S 0.5 YS/YS LAQ/LAQ ND ND ND 1752
YM140518 Urine 2 134 S 0.25 YS/YS LAQ/LAQ ND ND ND 1747
YM140896 Blood 5 911 S 0.25 YS/YS LTS/LTS 1.06 0.57 2.53 843
YM140912 Blood 5 910 S 0.5 YS/YS LAQ/LAQ ND ND ND 845
YM140977 Blood 5 140 S 0.25 YS/YS LTS/LTS ND ND ND 1751
YM141031 Urine 4 667 S 0.25 YS/YS LAQ/LTS ND ND ND 847
YFA120622 Soil 5 928 S ≤2 YS/YS LAQ/LAQ ND ND ND 818
YFA120679 Hand 5 140 S ≤2 YS/YS LTS/LTS ND ND ND 1749
YFA120727 Fruit 8 169 S ≤2 YS/YS LAQ/LAQ ND ND ND 1755
YFA120766 Fruit 1 587 S ≤2 YS/YS LAQ/LAQ ND ND ND 827
YFA121078 Soil 4 225 S ≤2 YS/FF LAQ/PTS 1.12 0.8 1.41 1758
YFA121513 Fruit 6 577 S ≤2 YS/YS LAQ/LAQ ND ND ND 817

*DST, diploid sequence type; ID, identification; MLST, multilocus sequence typing; ND, not determined; R, resistant; S, susceptible. †Locations of amino acid mutations in Erg11 and Upc2 proteins are indicated by numbers. Letter combinations indicate amino acid changes in both alleles of each isolate. Copy numbers of ERG11 gene are indicated in parentheses, when >1 copy per allele was present. ‡Numbers are fold change in mRNA levels for each gene compared with the control strain (YFA120877). §ID numbers are from the pubMLST database (https://pubmlst.org). ¶Clades were labeled with N followed by DST number if the isolates were not classified into a specific clade.

Main Article

1These authors contributed equally to this article.

Page created: September 04, 2024
Page updated: November 01, 2024
Page reviewed: November 01, 2024
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