Table 4

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Cost-effectiveness Analysis of Japanese Encephalitis Vaccination for Children <15 Years of Age, Bangladesh

An Nguyen¹, Rebeca Sultana¹

, Elisabeth Vodicka, Zareen Tasnim, Kamran Mehedi, Md. Monjurul Islam, S.M. Abdullah Al Murad, Md. Redowan Ullah, Sharmin Sultana, Tahmina Shirin, and Clint Pecenka

Author affiliation: Program for Appropriate Technology in Health (PATH), Ho Chi Minh City, Vietnam (A. Nguyen); icddr,b, Dhaka, Bangladesh (R. Sultana, Z. Tasnim, M.R. Ullah); PATH, Seattle, Washington, USA (E. Vodicka, C. Pecenka); PATH, Dhaka (K. Mehedi); Maternal, Newborn, Child and Adolescent Health, Dhaka (M.M. Islam, S.M.A. Al Murad); Institute of Epidemiology Diseases Control and Research, Dhaka (S. Sultana, T. Shirin)

Main Article

Discounted incremental costs of different Japanese encephalitis vaccination strategies as compared with no vaccination from the governmental payer and societal perspectives in Bangladesh*

Discounted incremental outcomes	Routine immunization birth cohorts	Strategy 1, subnational campaign + subnational routine†		Strategy 2, subnational campaign + national routine‡		Strategy 3, national routine§
Discounted incremental outcomes	Routine immunization birth cohorts	Govt	Soc	Govt	Soc	Govt	Soc
Discounted healthcare costs averted through vaccination	10	5.3M	55.8M	8.5M	90.1M	5.7M	60.1M
Discounted healthcare costs averted through vaccination	20	7.1M	75.1M	12.7M	134.8M	9.9M	104.8M
Deterministic ICER: cost per DALY averted	10	892	23	955	60	1,066	126
Deterministic ICER: cost per DALY averted	20	981	94	1,053	143	1,149	208
Deterministic ICER: cost per case averted	10	9,046	230	9,710	609	10,888	1,283
Deterministic ICER: cost per case averted	20	9,964	958	10,720	1,458	11,733	2,128
Deterministic ICER: cost per death averted	10	45,230	1,148	48,549	3,045	54,441	6,413
Deterministic ICER: cost per death averted	20	49,819	4,790	53,601	7,290	58,667	10,640
Probabilistic ICER: cost per DALY averted, mean (95% CI)	10	991 (358–2,272)	173 (–632 to 1,719)	1,351 (453–3,469)	196 (–501 to 2,614)	1,374 (439–3,557)	445 (–644 to 2,430)
Probabilistic ICER: cost per DALY averted, mean (95% CI)	20	1,198 (444 to 2,807)	307 (–538 to 1,971)	1,249 (352 to 2,684)	377 (–593 to 2,520)	1,394 (559 to 2,834)	560 (–475 to 2,879)
*Values are in US dollars. DALY, disability-adjusted life year; ICER, incremental cost-effectiveness ratio; govt, governmental costs; soc, societal costs. †Subnational 1-time immunization campaign for children <15 years of age and subnational routine immunization for 9-month-old children. The subnational approach focuses on 3 divisions with a high number of JE cases: Rangpur, Rajshahi, and Chattogram. ‡Subnational 1-time immunization campaign and national routine immunization. §National routine immunization only.

Main Article

¹These first authors contributed equally to this article.

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