Characteristics of Madariaga and Venezuelan Equine Encephalitis Virus Infections, Panama
Luis Felipe Rivera
1, Carlos Lezcano-Coba
1, Josefrancisco Galué, Xacdiel Rodriguez, Yelissa Juarez, William M. de Souza, Zeuz Capitan-Barrios, Anayansi Valderrama, Leyda Abrego, Hector Cedeño, Carmela Jackman, Jesse J. Waggoner, Patricia V. Aguilar, Hilda Guzman, Scott C. Weaver, Robert B. Tesh, Sandra López-Vèrges, Christl A. Donnelly, Cassia F. Estofolete, Mauricio L. Nogueira, Nuno R. Faria, Nikos Vasilakis, Amy Y. Vittor
2, Darci R. Smith
2 , and Jean-Paul Carrera
2
Author affiliation: Instituto Conmemorativo Gorgas de Estudios de la Salud, Panama City, Panama (L.F. Rivera, C. Lezcano-Coba, J. Galué, X. Rodriguez, Y. Juarez, A. Valderrama, L. Abrego, S. López-Vèrges, J.-P. Carrera); Carson Centre for Health and Ecosystem Research, La Peñita, Darién, Panama (L.F. Rivera, C. Lezcano-Coba, J. Galué, X. Rodriguez, Y. Juarez, Z. Capitan-Barrios, A. Valderrama, L. Abrego, J.-P. Carrera); Facultad Salud Pública y Administración, Universidad Peruana Cayetano Heredia, Lima, Peru (C. Lezcano-Coba); University of Kentucky, College of Medicine, Lexington, Kentucky, USA (W.M. de Souza); Universidad de Panamá, Ciudad de Panamá (Z. Capitan-Barrios, L. Abrego); Ministry of Health, Panama City (H. Cedeño, C. Jackman); Emory University, Atlanta, Georgia, USA (J.J. Waggoner), The University of Texas Medical Branch, Galveston, Texas, USA (P.V. Aguilar, H. Guzman, S.C. Weaver, R.B. Tesh, M.L. Nogueira, N. Vasilakis); University of Oxford, Oxford, UK (C.A. Donnelly, J.-P. Carrera); Faculdade de Medicina de São José do Rio Preto, São Paulo, Brazil (C.F. Estofolete, M.L. Nogueira); Imperial College London, London, UK (N.R. Faria); Faculdade de Medicina da Universidade de São Paulo, São Paulo (N.R. Faria); University of Florida, Gainesville, Florida, USA (A.Y. Vittor); Naval Medical Research Command, Fort Detrick, Maryland, USA (D.R. Smith)
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Figure 1
Figure 1. General laboratory algorithm used for diagnosis of MADV and VEEV, Panama. MADV and VEEV diagnosis made on the basis of days since symptom onset. *In paired samples showing 4-fold increase in antibody titers. †Confirmation after IgG or IgM testing. MADV, Madariaga virus; PRNT, plaque-reduction neutralization test; RT-PCR, reverse transcription PCR; VEEV, Venezuelan equine encephalitis virus.
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