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Volume 30, Supplement—October 2024
SUPPLEMENT ISSUE
Articles

Genomic Epidemiology of Multidrug-Resistant Escherichia coli and Klebsiella pneumoniae in Kenya, Uganda, and Jordan

Denis K. ByarugabaComments to Author , Tamer S. Osman, Omar M. Sayyouh, Godfrey Wokorach, Collins K. Kigen, James W. Muturi, Vanessa N. Onyonyi, Mayar M. Said, Salwa A. Nasrat, Mahmoud Gazo, Bernard Erima, Stephen Alafi, Hope O. Kabatesi, Fred Wabwire-Mangen, Hannah Kibuuka, Anjali P. Sapre, Katelyn V. Bartlett, Francois Lebreton, Melissa J. Martin, Evelyn W. Mahugu, Hunter J. Smith, and Lillian A. Musila
Author affiliation: Makerere University College of Veterinary Medicine, Kampala, Uganda (D.K. Byarugaba); Makerere University Walter Reed Project, Kampala (D.K. Byarugaba, G. Wokorach, B. Erima, S. Alafi, H.O Kabatesi, F. Wabwire-Mangen, H. Kibuuka); US Naval Medical Research Unit EURAFCENT, Cairo, Egypt (T.S. Osman, O.M. Sayyouh, M.M. Said, S.A. Nasrat); Muni University, Arua, Uganda (G. Wokorach); Kenya Medical Research Institute/Walter Reed Army Institute of Research Africa, Nairobi, Kenya (C.K. Kigen, J.W. Muturi, V.N. Onyonyi, L. Musila); Kenya Medical Research Institute, Kisumu City, Kenya (C.K. Kigen, J.W. Muturi, V.N. Onyonyi, L.A. Musila); Ministry of Health, Amman, Jordan (M. Gazo); Makerere University School of Public Health, Kampala (F. Wabwire-Mangen); Walter Reed National Military Medical Center Multidrug-Resistant Organism Repository and Surveillance Network, Silver Spring, Maryland, USA (A.P. Sapre, K.V. Bartlett, F. Lebreton, M.J. Martin); General Dynamics Information Technology, Silver Spring (E.W. Mahugu); US Military Armed Forces Health Surveillance Division, Silver Spring (E.W. Mahugu, H.J. Smith)

Main Article

Table

Demographic and clinical characteristics of patients from whom isolates were collected in study of genomic epidemiology of multidrug-resistant Escherichia coli and Klebsiella pneumoniae in Kenya, Uganda, and Jordan

Variable Escherichia coli, no. (%)
 Klebsiella pneumoniae, no. (%)
Kenya, n = 430 Uganda, n = 207 Jordan, n = 148 Kenya, n = 97 Uganda, n = 69 Jordan, n = 212
Age groups, y
0–4 7.2 (31) 1.9 (4) 19.6 (29) 7.2 (7) 7.2 (5) 26.9 (57)
5–9 1.9 (8) 0 5.4 (8) 0 1.4 (1) 4.7 (10)
10–17 2.1 (9) 3.4 (7) 4.1 (6) 3.1 (3) 0 4.2 (9)
18–49 61.4 (264) 67.6 (140) 22.3 (33) 60.8 (59) 58 (40) 22.6 (48)
>50 27.4 (118) 24.2 (50) 45.9 (68) 28.9 (28) 27.5 (19) 41.5 (88)
Not available
 0
 2.9 (6)
 2.7 (4)
0
 5.8 (4)
 0
Sex
M 47.4 (204) 37.7 (78) 59.5 (88) 60.8 (59) 56.5 (39) 75.0 (159)
F 51.9 (223) 62.3 (129) 40.5 (60) 39.2 (38) 42.0 (29) 25.0 (53)
Not available
 0.7 (3)
0
0
 1.4 (1)
 0
Infection type
CAI 81.4 (350) 48.8 (101) 48.0 (71) 68.0 (66) 33.33 (23) 14.2 (30)
HAI 15.8 (68) 42.5 (88) 52.0 (77) 28.9 (28) 56.52 (39) 85.8 (182)
Not available
 2.8 (12)
 8.7 (18)
 0
3.1 (3)
 10.14 (7)
 0
Year of isolation
2011 0 0 0 0 0 0.5 (1)
2012 0 0 6.8 (10) 0 0 9.0 (19)
2013 0 1.0 (2) 16.2 (24) 0 0 14.2 (30)
2014 0 0 18.2 (27) 0 0 7.1 (15)
2015 7.7 (33) 10.1 (21) 26.4 (39) 4.1 (4) 7.2 (5) 34.0 (72)
2016 4.2 (18) 9.7 (20) 21.6 (32) 3.1 (3) 21.7 (15) 21.2 (45)
2017 7.4 (32) 7.7 (16) 3.4 (5) 10.3 (10) 10.1 (7) 10.8 (23)
2018 25.6 (110) 5.8 (12) 4.1 (6) 29.9 (29) 5.8 (4) 0.9 (2)
2019 19.8 (85) 4.3 (9) 3.4 (5) 17.5 (17) 5.8 (4) 2.4 (5)
2020 6.7 (29) 13.5 (28) 0 5.2 (5) 7.2 (5) 0
2021 15.3 (66) 22.2 (46) 0 21.6 (21) 30.4 (21) 0
2022
 13.3 (57)
 25.6 (53)
 0
8.2 (8)
 11.6 (8)
 0
Sample type
Wound/skin 49.1 (211) 10.6 (22) 11.5 (17) 71.1 (69) 2.9 (2) 0.9 (2)
Urine 39.3 (169) 57.5 (119) 34.5 (51) 20.6 (20) 39.1 (27) 11.8 (25)
Blood 0.2 (1) 1.0 (2) 20.3 (30) 0.0 2.9 (2) 20.8 (44)
Pus 8.4 (36) 29.5 (61) 0 7.2 (7) 43.5 (30) 0
Throat 0.5 (2) 0 0 0 0 0
Respiratory 0.0 (2) 0 33.8 (50) 0 2.9 (2) 66.5 (141)
Other 2.1 (9) 1.4 (3) 0 1.0 (1) 8.7 (6) 0
Not available 0.5 (2) 10.6 (22) 0 0 0 0

* CAI, community-acquired infection; HAI, healthcare-associated infection.

Main Article

Page created: October 30, 2024
Page updated: November 11, 2024
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