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Volume 30, Number 8—August 2024
Research

Standardized Phylogenetic Classification of Human Respiratory Syncytial Virus below the Subgroup Level

Stephanie Goya1Comments to Author , Christopher Ruis2, Richard A. Neher2, Adam Meijer, Ammar Aziz, Angie S. Hinrichs, Anne von Gottberg, Cornelius Roemer, Daniel G. Amoako3, Dolores Acuña, Jakob McBroome, James R. Otieno, Jinal N. Bhiman, Josie Everatt, Juan C. Muñoz-Escalante, Kaat Ramaekers4, Kate Duggan, Lance D. Presser, Laura Urbanska, Marietjie Venter, Nicole Wolter, Teresa C.T. Peret, Vahid Salimi, Varsha Potdar, Vítor Borges, and Mariana Viegas1
Author affiliations: University of Washington, Seattle, Washington, USA (S. Goya); University of Cambridge, Cambridge, UK (C. Ruis); University of Basel and SIB, Basel, Switzerland (R.A. Neher, C. Roemer, L. Urbanska); National Institute for Public Health and the Environment, Bilthoven, the Netherlands (A. Meijer, L.D. Presser); World Health Organization Collaborating Centre for Reference and Research on Influenza, Melbourne, Victoria, Australia (A. Aziz); University of California Santa Cruz, Santa Cruz, California, USA (A.S. Hinrichs, J. McBroome); National Institute for Communicable Diseases of the National Health Laboratory Service, Johannesburg, South Africa (A. von Gottberg, J.N. Bhiman, J. Everatt, N. Wolter); University of Witwatersrand, Johannesburg, South Africa (A. von Gottberg, J.N. Bhiman, N. Wolter); University of KwaZulu-Natal, Durban, South Africa (D.G. Amoako); Universidad Nacional de La Plata, Buenos Aires, Argentina (D. Acuña, M. Viegas); National Scientific and Technical Research Council, Buenos Aires, Argentina (D. Acuña, M. Viegas); Theiagen Genomics, Highlands Ranch, Colorado, USA (J.R. Otieno); Autonomous University of San Luis Potosí, San Luis Potosí, Mexico (J.C. Muñoz-Escalante); Rega Institute for Medical Research, Leuven, Belgium (K. Ramaekers); University of Edinburgh, Edinburgh, Scotland, UK (K. Duggan); University of Pretoria, Pretoria, South Africa (M. Venter); University of Texas Medical Branch, Galveston, Texas, USA (T.C.T. Peret); Tehran University of Medical Sciences, Tehran, Iran (V. Salimi); ICMR National Institute of Virology, Pune, India (V. Potdar); National Institute of Health Doutor Ricardo Jorge, Lisbon, Portugal (V. Borges)

Main Article

Figure 1

The structure and genome of human respiratory syncytial virus (HRSV). A) Schematic of the HRSV virion structure detailing the location of structural proteins. B) Schematic of the HRSV genome organization with the approximated location of genes highlighted; the exact location slightly differs between subgroups and strains. The location of the second hypervariable region in the G gene, used originally for molecular epidemiology classification, is detailed. Red arrow in panel B indicates location of the G gene 72-nt duplication in HRSV-A and 60-nt duplication in HRSV-B. Figure created with BioRender (https://www.biorender.com). F, fusion glycoprotein; G, attachment glycoprotein; L, large polymerase protein; M, matrix protein; M2, M2 protein; N, nucleocapsid; NS, nonstructural protein; ORF, open reading frame; P, phosphoprotein; SH, small hydrophobic protein.

Figure 1. The structure and genome of human respiratory syncytial virus (HRSV). A) Schematic of the HRSV virion structure detailing the location of structural proteins. B) Schematic of the HRSV genome organization with the approximated location of genes highlighted; the exact location slightly differs between subgroups and strains. The location of the second hypervariable region in the G gene, used originally for molecular epidemiology classification, is detailed. Red arrow in panel B indicates location of the G gene 72-nt duplication in HRSV-A and 60-nt duplication in HRSV-B. Figure created with BioRender (https://www.biorender.com). F, fusion glycoprotein; G, attachment glycoprotein; L, large polymerase protein; M, matrix protein; M2, M2 protein; N, nucleocapsid; NS, nonstructural protein; ORF, open reading frame; P, phosphoprotein; SH, small hydrophobic protein.

Main Article

1These authors were co–principal investigators.

2These authors contributed equally to this article.

3Current affiliation: Department of Pathobiology, University of Guelph, Guelph, Ontario, Canada.

4Current affiliation: Sciensano, Infectious Diseases in Humans, Unit (Re)-Emerging Viruses, Brussels, Belgium.

Page created: June 21, 2024
Page updated: July 20, 2024
Page reviewed: July 20, 2024
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