Volume 30, Number 9—September 2024
Research
Formation of Single-Species and Multispecies Biofilm by Isolates from Septic Transfusion Reactions in Platelet Bag Model
Table
Acinetobacter spp. bacteria–related and polymicrobial septic transfusion reactions, United States, May 2018–July 2021*
Year and month | Location (outcome) | Risk mitigation (result) | Bacterial species |
---|---|---|---|
2018 May | Northern California | Pathogen-reduction technology | A–S† |
2018 May | Utah (fatality) | Aerobic culture (neg) | A |
2018 Oct | Connecticut‡ | Aerobic culture (neg), rapid antigen test (neg) | A–S |
2018 Oct | Connecticut‡ | Aerobic culture (neg), rapid antigen test (neg) | A–S |
2020 Jun | North and South Carolina (fatality) | Pathogen-reduction technology | A–S–L |
2020 Jun | Central Ohio, Pennsylvania, New Jersey | Aerobic culture (neg), anaerobic culture (neg) | A§ |
2021 Jul | Ohio (fatality) | Pathogen-reduction technology | A–S–L† |
2021 Jul |
Virginia |
Pathogen-reduction technology |
S–L |
*A, Acinetobacter spp.; L, Leclercia adecarboxylata; neg, negative; S, Staphylococcus saprophyticus. †Clinical isolates used in the experiments. ‡Two separate reactions from a double platelet. §Case was excluded from Acinetobacter spp. cluster investigation by Centers for Disease Control and Prevention and US Food and Drug Administration based on whole-genome sequencing data (5,36). |
References
- Food and Drug Administration. Important information for blood establishments and transfusion services regarding bacterial contamination of platelets for transfusion. 2021 Dec 2 [cited 2024 Dec 15]. https://www.fda.gov/vaccines-blood-biologics/safety-availability-biologics/important-information-blood-establishments-and-transfusion-services-regarding-bacterial
- Fridey JL, Stramer SL, Nambiar A, Moayeri M, Bakkour S, Langelier C, et al. Sepsis from an apheresis platelet contaminated with Acinetobacter calcoaceticus/baumannii complex bacteria and Staphylococcus saprophyticus after pathogen reduction. Transfusion. 2020;60:1960–9. DOIPubMedGoogle Scholar
- Jones SA, Jones JM, Leung V, Nakashima AK, Oakeson KF, Smith AR, et al. Sepsis attributed to bacterial contamination of platelets associated with a potential common source—multiple states, 2018. MMWR Morb Mortal Wkly Rep. 2019;68:519–23. DOIPubMedGoogle Scholar
- Kracalik I, Kent AG, Villa CH, Gable P, Annambhotla P, McAllister G, et al. Posttransfusion sepsis attributable to bacterial contamination in platelet collection set manufacturing facility, United States. Emerg Infect Dis. 2023;29:1979–89. DOIPubMedGoogle Scholar
- Villa CH, Illoh O, Kracalik I, Basavaraju SV, Eder AF. Posttransfusion sepsis attributable to bacterial contamination in platelet collection set manufacturing, United States. Transfusion. 2023;63:2351–7. DOIPubMedGoogle Scholar
- Food and Drug Administration. Important information for blood establishments and transfusion services regarding bacterial contamination of platelets for transfusion. 2022 Dec 22 [cited 2023 Dec 15]. https://www.fda.gov/vaccines-blood-biologics/safety-availability-biologics/important-information-blood-establishments-and-transfusion-services-regarding-bacterial
- Ledwoch K, Dancer SJ, Otter JA, Kerr K, Roposte D, Rushton L, et al. Beware biofilm! Dry biofilms containing bacterial pathogens on multiple healthcare surfaces; a multi-centre study. J Hosp Infect. 2018;100:e47–56. DOIPubMedGoogle Scholar
- Moris V, Lam M, Amoureux L, Magallon A, Guilloteau A, Maldiney T, et al. What is the best technic to dislodge Staphylococcus epidermidis biofilm on medical implants? BMC Microbiol. 2022;22:192. DOIPubMedGoogle Scholar
- Sharma S, Mohler J, Mahajan SD, Schwartz SA, Bruggemann L, Aalinkeel R. Microbial biofilm: a review on formation, infection, antibiotic resistance, control measures, and innovative treatment. Microorganisms. 2023;11:1614. DOIPubMedGoogle Scholar
- Didouh N, Khadidja M, Campos C, Sampaio-Maia B, Boumediene MB, Araujo R. Assessment of biofilm, enzyme production and antibiotic susceptibility of bacteria from milk pre- and post-pasteurization pipelines in Algeria. Int J Food Microbiol. 2023;407:
110389 . DOIPubMedGoogle Scholar - Zeighami H, Valadkhani F, Shapouri R, Samadi E, Haghi F. Virulence characteristics of multidrug resistant biofilm forming Acinetobacter baumannii isolated from intensive care unit patients. BMC Infect Dis. 2019;19:629. DOIPubMedGoogle Scholar
- Gedefie A, Demsis W, Ashagrie M, Kassa Y, Tesfaye M, Tilahun M, et al. Acinetobacter baumannii biofilm formation and its role in disease pathogenesis: a review. Infect Drug Resist. 2021;14:3711–9. DOIPubMedGoogle Scholar
- Kerantzas CA, Merwede J, Snyder EL, Hendrickson JE, Tormey CA, Kazmierczak BI, et al. Assessment of polymicrobial interactions in bacterial isolates from transfused platelet units associated with sepsis. Transfusion. 2022;62:2458–63. DOIPubMedGoogle Scholar
- Lawal OU, Barata M, Fraqueza MJ, Worning P, Bartels MD, Goncalves L, et al. Staphylococcus saprophyticus from clinical and environmental origins have distinct biofilm composition. Front Microbiol. 2021;12:
663768 . DOIPubMedGoogle Scholar - Colquhoun JM, Rather PN. Insights into mechanisms of biofilm formation in Acinetobacter baumannii and implications for uropathogenesis. Front Cell Infect Microbiol. 2020;10:253. DOIPubMedGoogle Scholar
- Gottesman T, Fedorowsky R, Yerushalmi R, Lellouche J, Nutman A. An outbreak of carbapenem-resistant Acinetobacter baumannii in a COVID-19 dedicated hospital. Infect Prev Pract. 2021;3:
100113 . DOIPubMedGoogle Scholar - Perez S, Innes GK, Walters MS, Mehr J, Arias J, Greeley R, et al. Increase in hospital-acquired carbapenem-resistant Acinetobacter baumannii infection and colonization in an acute care hospital during a surge in COVID-19 admissions—New Jersey, February–July 2020. MMWR Morb Mortal Wkly Rep. 2020;69:1827–31. DOIPubMedGoogle Scholar
- Upmanyu K, Haq QMR, Singh R. Factors mediating Acinetobacter baumannii biofilm formation: Opportunities for developing therapeutics. Curr Res Microb Sci. 2022;3:
100131 . DOIPubMedGoogle Scholar - Wong D, Nielsen TB, Bonomo RA, Pantapalangkoor P, Luna B, Spellberg B. Clinical and pathophysiological overview of Acinetobacter infections: a century of challenges. Clin Microbiol Rev. 2017;30:409–47. DOIPubMedGoogle Scholar
- Hadjesfandiari N, Schubert P, Fallah Toosi S, Chen Z, Culibrk B, Ramirez-Arcos S, et al. Effect of texture of platelet bags on bacterial and platelet adhesion. Transfusion. 2016;56:2808–18. DOIPubMedGoogle Scholar
- Loza-Correa M, Kalab M, Yi QL, Eltringham-Smith LJ, Sheffield WP, Ramirez-Arcos S. Comparison of bacterial attachment to platelet bags with and without preconditioning with plasma. Vox Sang. 2017;112:401–7. DOIPubMedGoogle Scholar
- Wilson-Nieuwenhuis JST, Dempsey-Hibbert N, Liauw CM, Whitehead KA. Surface modification of platelet concentrate bags to reduce biofilm formation and transfusion sepsis. Colloids Surf B Biointerfaces. 2017;160:126–35. DOIPubMedGoogle Scholar
- Taha M, Culibrk B, Kalab M, Schubert P, Yi QL, Goodrich R, et al. Efficiency of riboflavin and ultraviolet light treatment against high levels of biofilm-derived Staphylococcus epidermidis in buffy coat platelet concentrates. Vox Sang. 2017;112:408–16. DOIPubMedGoogle Scholar
- Hapip CA, Brown BL. The role of biofilms in the blood center environment. American Association for Advancement of Blood and Biotherapies. 2022 [cited 2022 Oct 21]. https://aabb.confex.com/aabb/2022/meetingapp.cgi/Paper/10736
- Allkja J, Bjarnsholt T, Coenye T, Cos P, Fallarero A, Harrison JJ, et al. Minimum information guideline for spectrophotometric and fluorometric methods to assess biofilm formation in microplates. Biofilm. 2019;2:
100010 . DOIPubMedGoogle Scholar - Sandbakken ET, Witsø E, Sporsheim B, Egeberg KW, Foss OA, Hoang L, et al. Highly variable effect of sonication to dislodge biofilm-embedded Staphylococcus epidermidis directly quantified by epifluorescence microscopy: an in vitro model study. J Orthop Surg Res. 2020;15:522. DOIPubMedGoogle Scholar
- Ahmad I, Nadeem A, Mushtaq F, Zlatkov N, Shahzad M, Zavialov AV, et al. Csu pili dependent biofilm formation and virulence of Acinetobacter baumannii. NPJ Biofilms Microbiomes. 2023;9:101. DOIPubMedGoogle Scholar
- Nyanasegran PK, Nathan S, Firdaus-Raih M, Muhammad NAN, Ng CL. Biofilm signaling, composition and regulation in Burkholderia pseudomallei. J Microbiol Biotechnol. 2023;33:15–27. DOIPubMedGoogle Scholar
- Ali H, Greco-Stewart VS, Jacobs MR, Yomtovian RA, Rood IGH, de Korte D, et al. Characterization of the growth dynamics and biofilm formation of Staphylococcus epidermidis strains isolated from contaminated platelet units. J Med Microbiol. 2014;63:884–91. DOIPubMedGoogle Scholar
- Loza-Correa M, Yousuf B, Ramirez-Arcos S. Staphylococcus epidermidis undergoes global changes in gene expression during biofilm maturation in platelet concentrates. Transfusion. 2021;61:2146–58. DOIPubMedGoogle Scholar
- Greco-Stewart VS, Brown EE, Parr C, Kalab M, Jacobs MR, Yomtovian RA, et al. Serratia marcescens strains implicated in adverse transfusion reactions form biofilms in platelet concentrates and demonstrate reduced detection by automated culture. Vox Sang. 2012;102:212–20. DOIPubMedGoogle Scholar
- Fadeyi EA, Wagner SJ, Goldberg C, Lu T, Young P, Bringmann PW, et al. Fatal sepsis associated with a storage container leak permitting platelet contamination with environmental bacteria after pathogen reduction. Transfusion. 2021;61:641–8. DOIPubMedGoogle Scholar
- Spindler-Raffel E, Benjamin RJ, McDonald CP, Ramirez-Arcos S, Aplin K, Bekeredjian-Ding I, et al.; ISBT Working Party Transfusion-Transmitted Infectious Diseases (WP-TTID), Subgroup on Bacteria. Enlargement of the WHO international repository for platelet transfusion-relevant bacteria reference strains. Vox Sang. 2017;112:713–22. DOIPubMedGoogle Scholar
- Fux CA, Uehlinger D, Bodmer T, Droz S, Zellweger C, Mühlemann K. Dynamics of hemodialysis catheter colonization by coagulase-negative staphylococci. Infect Control Hosp Epidemiol. 2005;26:567–74. DOIPubMedGoogle Scholar
- Food and Drug Administration. Bacterial risk control strategies for blood collection establishments and transfusion services to enhance the safety and availability of platelets for transfusion. 2020 Dec [cited 2023 Dec 15]. https://www.fda.gov/regulatory-information/search-fda-guidance-documents/bacterial-risk-control-strategies-blood-collection-establishments-and-transfusion-services-enhance
- Kracalik I, Sapiano MRP, Wild RC, Chavez Ortiz J, Stewart P, Berger JJ, et al. Supplemental findings of the 2021 National Blood Collection and Utilization Survey. Transfusion. 2023;63(Suppl 4):S19–42. DOIPubMedGoogle Scholar
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Page updated: August 20, 2024
Page reviewed: August 20, 2024
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