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Volume 30, Number 9—September 2024
Dispatch

Avian and Human Influenza A Virus Receptors in Bovine Mammary Gland

Charlotte KristensenComments to Author , Henrik E. Jensen, Ramona Trebbien, Richard J. Webby, and Lars E. Larsen
Author affiliations: University of Copenhagen, Frederiksberg, Denmark (C. Kristensen, H.E. Jensen, L.E. Larsen); Statens Serum Institut, Copenhagen, Denmark (R. Trebbien); St. Jude Children’s Research Hospital, Memphis, Tennessee, USA (R.J. Webby)

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Table

The average percentage of epithelial staining of the human and duck influenza A virus receptors in the alveoli and ducts in 9 cows with different breeds, ages, and parity status*.

Breed Age, y Parity Lactation‡ % SNA
 % MAA-II,† alveoli
Alveoli Ducts
Jersey
 6
 4
 Late
 53
18
37
Danish Holstein 4 2 Late 57 3 47
7 5 Late 40 21 46
6 4 Early/mid 47 4 44
5 2 Late 58 24 61
6 4 Early/mid 51 10 49
5 3 Early/mid 55 1 51
4
 3
 Late
 52
32
48
Unknown
 Unknown
 Unknown
 Early/mid
 59
6
47
Average 5 3 NA 54 13 48

*MAA-II, duck receptor; NA, not applicable; SNA, human receptor. †The staining did not exceed the amount of staining observed with the neuraminidase treatment suggesting a nonspecific staining in the ducts. ‡All images were obtained from active alveoli of the mammary glands and the staining is therefore not representative for the whole section of cows in late lactation. The lactation period was determined by investigating the luminal size of the alveoli and the amount of connective tissue (12).

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Page updated: August 09, 2024
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