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Detection of Prions in Wild Pigs (Sus scrofa) from Areas with Reported Chronic Wasting Disease Cases, United States
Paulina Soto, Francisca Bravo-Risi, Rebeca Benavente, Tucker H. Stimming, Michael J. Bodenchuk, Patrick Whitley, Clint Turnage, Terry R. Spraker, Justin Greenlee, Glenn Telling, Jennifer Malmberg, Thomas Gidlewski, Tracy Nichols, Vienna R. Brown, and Rodrigo Morales
Author affiliation: The University of Texas Health Science Center at Houston, Texas, USA (P. Soto, F. Bravo-Risi, R. Benavente, T.H. Stimming, R. Morales); Centro Integrativo de Biologia y Quimica Aplicada, Universidad Bernardo O’Higgins, Santiago, Chile (P. Soto, F. Bravo-Risi, R. Morales); US Department of Agriculture, Fort Collins, Colorado, USA (M.J. Bodenchuk, P. Whitley, C. Turnage, J. Malmberg, T. Gidlewski, T. Nichols, V.R. Brown); Colorado State University, Fort Collins, Colorado, USA (T.R. Spraker, G. Telling); US Department of Agriculture, Ames, Iowa, USA (J. Greenlee)
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Figure 4
Figure 4. Prion detection using porcine-PMCA in wild pig tissues originating from a CWD-endemic region of Texas, USA, in a study of prions in wild pigs (Sus scrofa) from areas with reported chronic wasting disease cases. A) Experimental strategy depicting tissues analyzed in animals from this cohort and PMCA settings. B) Graphs representing percentage of detection per tissue. Grey samples are representative of no detection. C) Details on the prion detection data displayed in panel B. CWD, chronic wasting disease; PMCA, protein misfolding cyclic amplification; PrP, prion proteins; RPLN, retropharyngeal lymph nodes; SMLN, submandibular lymph nodes; Tg, transgenic.
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