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Volume 31, Number 10—October 2025

Research

Multidrug-Resistant pESI-Harboring Salmonella enterica Serovar Muenchen Sequence Type 82 in Poultry and Humans, Israel, 2020–2023

Janet Perry, Tal Rakler, Katya Arnold, Anat Wiseman, Cinthia Satuchne, Yaniv Pima, Galina Moiseeva, Ilana Maler, Eugenia Yakunin, Assaf Rokney, and Ehud ElnekaveComments to Author 
Author affiliation: Hebrew University of Jerusalem Robert H Smith Faculty of Agriculture Food and Environment, Rehovot, Israel (J. Perry, T. Rakler, K. Arnold, E. Elnekave); Egg and Poultry Board, Re'em Masmiya, Israel (A. Wiseman, C. Satuchne, Y. Pima); Kimron Veterinary Institute, Beit Dagan, Israel (G. Moiseeva, I. Maler); State of Israel Ministry of Health, Jerusalem, Israel (E. Yakunin, A. Rokney)

Main Article

Table 2

Phenotypic resistance and presence of acquired antimicrobial resistance genes known to confer resistance in Salmonella enterica serovar Muenchen in study of Salmonella Muenchen in poultry and humans, Israel, 2020–2023*

Antimicrobial class and drug MIC cutoff, µg/mL No. infections/no. tested (%) Relevant AMR genes and point mutations present in tested isolates (no.)
Tetracyclines
Tetracycline
 16
 15/15 (100)†
 tetA (13), tetA + tetM (1)
Aminoglycosides
Streptomycin 32 14/15 (93.3) aadA1 (13), aadA1 + aadA2 (1)
Gentamicin
 16
 0/15 (0)
 None
Phenicols
Chloramphenicol
 32
 6/15 (40.0)†
 floR (4), floR + cmlA1 (1)
Penicillins
Ampicillin 32 7/15 (46.7)† blaTEM-1 (5), blaTEM-176 (1)
Amoxicillin/clavulanic acid, 2:1 ratio
 32/16
 0/15 (0)
 None
Cephalosporins
Cefoxitin 32 0/15 (0) None
Ceftriaxone
 4
 0/15 (0)
 None
Folate pathway antagonists
Sulfisoxazole 256 15/15† (100) sul1 (13), sul2 (1)
Trimethoprim/sulfamethoxazole
 4/76
 14/15† (93.3)
 dfrA14 + sul1 (10), dfrA14 (1), dfrA12 + dfrA14 + sul2 (1)
Quinolones
Ciprofloxacin 0.12‡ 11/15 (73.3) qnrB19 (7§), qnrS1 (3), gyrA S83F (1), qnrS1 + gyrA S83F (1)
Nalidixic acid
 32
 4/15 (26.7)
 qnrB19 (1), qnrS1 (1), gyrA S83F (1), qnrS1 + gyrA S83F (1)
Macrolides
Azithromycin
 32
 0/15 (0)
 None
Carbapenems
Meropenem 4 0/15 (0) None

*AMR, antimicrobial resistance; +, genes found simultaneously on the same isolate. †>1 isolates exhibited phenotypic resistance without the identification of a relevant AMR gene ‡MIC cutoff for decreased susceptibility as a marker for emerging fluoroquinolone resistance (20). §One isolate (Br04) harbored the qnrB19 gene but was sensitive to ciprofloxacin (MIC = 0.03 µg/mL)

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