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Volume 31, Number 11—November 2025

Research

Two Independent Acquisitions of Multidrug Resistance Gene lsaC in Streptococcus pneumoniae Serotype 20 Multilocus Sequence Type 1257

Bernard BeallComments to Author , Wuling Lin, Zhongya Li, Theresa Tran, Benjamin J. Metcalf, Bridget J. Anderson, Keipp H. Talbot, Lesley McGee, and Sopio Chochua
Author affiliation: ASRT, Inc., Smyrna, Georgia, USA (B. Beall, Z. Li); Centers for Disease Control and Prevention, Atlanta, Georgia, USA (W. Lin, T. Tran, B.J. Metcalf, L. McGee, S. Chochua); New York State Department of Health, Albany, New York, USA (B.J. Anderson); Vanderbilt University School of Medicine, Nashville, Tennessee, USA (K.H. Talbot)

Main Article

Figure 7

Related regions shared between the 2 pneumococcal lsaC elements from this study, the mobile element found in S. pseudopneumoniae 315_SP_SPSE, and the partial mobile element from GBS strain UCN70 in study of 2 independent acquisitions of multidrug resistance gene lsaC in serotype 20/ST1257 S. pneumoniae, United States. A) The lsaC element target site (oriT) is indicated in S. pseudopneumoniae 315_SPSE, with partially homologous junctions (j1 and j2) of the lsaC elements in the 3 strains (isolate 1–16, isolate 17, and S. agalactiae UCN70). B) The identical oriT sequence shared between related mobile elements lacking lsaC from 5 different species is shown. lsaC element junction j1 shares homology with the 5' oriT sequence and junction j2 shares homology with the 3′ oriT sequence. Purple indicates the shared C and G repeats; green indicates direct repeats between each of the 3 strains shared between their specific j1 and j2 sequences and homologous central oriT sequence. Bold indicates J1 and j2 bases shared with the oriT sequence. ST, sequence type.

Figure 7. Related regions shared between the 2 pneumococcal lsaC elements from this study, the mobile element found in S. pseudopneumoniae 315_SP_SPSE, and the partial mobile element from GBS strain UCN70 in study of 2 independent acquisitions of multidrug resistance gene lsaC in serotype 20/ST1257 S. pneumoniae, United States. A) The lsaC element target site (oriT) is indicated in S. pseudopneumoniae 315_SPSE, with partially homologous junctions (j1 and j2) of the lsaC elements in the 3 strains (isolate 1–16, isolate 17, and S. agalactiae UCN70). B) The identical oriT sequence shared between related mobile elements lacking lsaC from 5 different species is shown. lsaC element junction j1 shares homology with the 5' oriT sequence and junction j2 shares homology with the 3′ oriT sequence. Purple indicates the shared C and G repeats; green indicates direct repeats between each of the 3 strains shared between their specific j1 and j2 sequences and homologous central oriT sequence. Bold indicates J1 and j2 bases shared with the oriT sequence. ST, sequence type.

Main Article

Page created: September 19, 2025
Page updated: December 10, 2025
Page reviewed: December 10, 2025
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