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Volume 31, Number 11—November 2025

Research

Two Independent Acquisitions of Multidrug Resistance Gene lsaC in Streptococcus pneumoniae Serotype 20 Multilocus Sequence Type 1257

Bernard BeallComments to Author , Wuling Lin, Zhongya Li, Theresa Tran, Benjamin J. Metcalf, Bridget J. Anderson, Keipp H. Talbot, Lesley McGee, and Sopio Chochua
Author affiliation: ASRT, Inc., Smyrna, Georgia, USA (B. Beall, Z. Li); Centers for Disease Control and Prevention, Atlanta, Georgia, USA (W. Lin, T. Tran, B.J. Metcalf, L. McGee, S. Chochua); New York State Department of Health, Albany, New York, USA (B.J. Anderson); Vanderbilt University School of Medicine, Nashville, Tennessee, USA (K.H. Talbot)

Main Article

Figure 6

Alignments between Streptococcus mitis strain, pneumococcal isolates 1–16, S. pseudopneumoniae strain 315_SPSE, and pansusceptible serotype 20/ST1257 pneumococcal strain (bottom) in study of independent acquisitions of multidrug resistance gene lsaC in serotype 20/ST1257 S. pneumoniae isolates, United States. This alignment depicts representative homology between certain streptococcal strains recognized as S. mitis and the genome flanking the resistance element in strains 1–16. Also shown is the near identity to this region shown by S. pseudopneumoniae strain 315_SPSE. The mobile elements (triangles) in isolates 1–16 and S. pseudopneumoniae 315_SPSE correspond to the mobile elements depicted in Figure 4. The apparent nonpneumococcal genes (brown) flank the mobile element introduced by recombination into isolates 1–16. Red arrows indicates the genomic region in the serotype 20/ST1257 corresponding to the mobile element insertion site. ST, sequence type.

Figure 6. Alignments between Streptococcus mitis strain, pneumococcal isolates 1–16, S. pseudopneumoniae strain 315_SPSE, and pansusceptible serotype 20/ST1257 pneumococcal strain (bottom) in study of independent acquisitions of multidrug resistance gene lsaC in serotype 20/ST1257 S. pneumoniae isolates, United States. This alignment depicts representative homology between certain streptococcal strains recognized as S. mitis and the genome flanking the resistance element in strains 1–16. Also shown is the near identity to this region shown by S. pseudopneumoniae strain 315_SPSE. The mobile elements (triangles) in isolates 1–16 and S. pseudopneumoniae 315_SPSE correspond to the mobile elements depicted in [[ANCHOR###F4###Figure 4###Anchor]]. The apparent nonpneumococcal genes (brown) flank the mobile element introduced by recombination into isolates 1–16. Red arrows indicates the genomic region in the serotype 20/ST1257 corresponding to the mobile element insertion site. ST, sequence type.

Main Article

Page created: September 19, 2025
Page updated: November 25, 2025
Page reviewed: November 25, 2025
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