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Volume 31, Number 12—December 2025

Dispatch

Abnormal Prion Protein in Nasal Swab Specimens of Macaques Infected with Creutzfeldt-Jakob Disease

Juraj Cervenak, Oksana Yakovleva, Cyrus Bett, Teresa Pilant, Kelly Rice, Lewis Shankle1, David M. Asher1, Luisa GregoriComments to Author , and Pedro Piccardo
Author affiliation: US Food and Drug Administration, Center for Biologics Evaluation and Research, Silver Spring, Maryland, USA (J. Cervenak, O. Yakovleva, C. Bett, T. Pilant, K. Rice, L. Shankle, D.M. Asher, L. Gregori); Unidad Académica de Neuropediátria, Universidad de la República, Montevideo, Uruguay (P. Piccardo)

Main Article

Figure 2

Immunohistochemistry for abnormal disease-associated prion protein (PrPTSE) and CD21 on inguinal lymph node of macaque 98CO19 for study of macaques infected with Creutzfeldt-Jakob disease. Adjacent sections were stained with hematoxylin-eosin (A); immunostained for PrPTSE (B) and CD21 (C); and probed without primary antibody as negative control (D). Original magnification ×40.

Figure 2. Immunohistochemistry for abnormal disease-associated prion protein (PrPTSE) and CD21 on inguinal lymph node of macaque 98CO19 for study of macaques infected with Creutzfeldt-Jakob disease. Adjacent sections were stained with hematoxylin-eosin (A); immunostained for PrPTSE (B) and CD21 (C); and probed without primary antibody as negative control (D). Original magnification ×40.

Main Article

1Retired.

Page created: December 13, 2025
Page updated: January 07, 2026
Page reviewed: January 07, 2026
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